Mohammadi Zahed, Jafarzadeh Hamid, Shalavi Sousan
Iranian Center for Endodontic Research, Shahid Beheshti University of Medical Sciences.
J Oral Sci. 2014 Jun;56(2):99-103. doi: 10.2334/josnusd.56.99.
Use of an appropriate root canal irrigant is essential during endodontic treatment, due to the complex and unpredictable anatomy of the root canal system and limitations in the mechanical instrumentation techniques used to obtain a clean, bacteria-free canal. Several irrigants, such as sodium hypochlorite, chlorhexidine, hydrogen peroxide, and normal saline, have been proposed as canal system irrigants in endodontic treatment. The widely used endodontic irrigant chlorhexidine is a positively charged lipophilic/hydrophobic molecule that interacts with phospholipids and lipopolysaccharides on the bacterial cell membrane. In endodontics, its mode of antibacterial activity is determined by its concentration (0.2% or 2%). This article reviews findings from available endodontic studies on the antibacterial, antifungal, and antibiofilm activities of chlorhexidine.
在根管治疗过程中，使用合适的根管冲洗剂至关重要，这是因为根管系统的解剖结构复杂且难以预测，同时用于获得清洁、无菌根管的机械预备技术也存在局限性。几种冲洗剂，如次氯酸钠、氯己定、过氧化氢和生理盐水，已被提议作为根管治疗中的根管系统冲洗剂。广泛使用的根管冲洗剂氯己定是一种带正电荷的亲脂性/疏水性分子，它与细菌细胞膜上的磷脂和脂多糖相互作用。在牙髓病学中，其抗菌活性模式取决于其浓度（0.2%或2%）。本文综述了现有牙髓病学研究中关于氯己定的抗菌、抗真菌和抗生物膜活性的研究结果。
