Kuruvilla J R, Kamath M P
Department of Conservative Dentistry and Endodontics, College of Dental Surgery, Mangalore, India.
J Endod. 1998 Jul;24(7):472-6. doi: 10.1016/S0099-2399(98)80049-6.
Sodium hypochlorite irrigant is known to be toxic to periapical tissues. Chlorhexidine gluconate, a safer and effective antimicrobial irrigant, is not known to dissolve pulpal tissues. To obtain their optimal properties, their combined action within the root canal was evaluated. Ten single rooted nonvital anterior teeth were irrigated using either 2.5% sodium hypochlorite alone, 0.2% chlorhexidine gluconate alone, 2.5% sodium hypochlorite and 0.2% chlorhexidine gluconate combined within the root canal, or 0.9% saline, respectively. Microbiological samples for culture and Gram's staining were taken before and proceeding irrigation. This study indicates that the use of sodium hypochlorite and chlorhexidine gluconate combined within the root canal resulted in the greatest percentage reduction of postirrigant positive cultures. This may be due to formation of "chlorhexidine chloride," which increases the ionizing capacity of the chlorhexidine molecule. This reduction was significant compared to use of sodium hypochlorite alone but not significant compared to use of chlorhexidine gluconate alone.
已知次氯酸钠冲洗剂对根尖周组织有毒性。葡萄糖酸氯己定是一种更安全有效的抗菌冲洗剂，它不会溶解牙髓组织。为了获得它们的最佳性能，对它们在根管内的联合作用进行了评估。分别使用以下方法冲洗10颗单根无活力前牙：单独使用2.5%的次氯酸钠、单独使用0.2%的葡萄糖酸氯己定、根管内联合使用2.5%的次氯酸钠和0.2%的葡萄糖酸氯己定，或使用0.9%的生理盐水。在冲洗前和冲洗后采集用于培养和革兰氏染色的微生物样本。本研究表明，根管内联合使用次氯酸钠和葡萄糖酸氯己定可使冲洗后阳性培养物的减少百分比最大。这可能是由于形成了“氯化氯己定”，它增加了氯己定分子的电离能力。与单独使用次氯酸钠相比，这种减少具有显著性，但与单独使用葡萄糖酸氯己定相比则无显著性。
