Ehlers Bernhard, Moens Ugo
Division 12 "Measles, Mumps, Rubella and Viruses Affecting Immunocompromised Patients", Robert Koch Institute, 13353 Berlin, Germany.
University of Tromsø, Faculty of Health Sciences, Department of Medical Biology, NO-9037 Tromsø, Norway.
Infect Genet Evol. 2014 Aug;26:283-94. doi: 10.1016/j.meegid.2014.05.030. Epub 2014 Jun 14.
Polyomaviruses have so far only been isolated from mammals and birds. Typical for all members of this family is their double-stranded genome of approximately 5000 base-pairs which can be divided into an early region encoding at least two functional proteins, the large and small tumor antigens, and a late region encompassing genes for the capsid proteins VP1 and VP2. During the last 10 years several novel polyomaviruses have been described in non-human primates and man. This review compares the non-human primate polyomavirus genomes that have been completely sequenced with each other and with the genomes of human polyomaviruses. We predict the presence of protein- and microRNA-encoding sequences. Our analyses demonstrate that several genetically distinct groups of non-human primate polyomaviruses exist, that different polyomaviruses can infect the same non-human primate species but that most of their proteins display highly similar domains and motifs, indicating conservation of key functions.
迄今为止，多瘤病毒仅从哺乳动物和鸟类中分离出来。该病毒家族所有成员的典型特征是其双链基因组，约有5000个碱基对，可分为早期区域和晚期区域，早期区域编码至少两种功能蛋白，即大肿瘤抗原和小肿瘤抗原，晚期区域包含衣壳蛋白VP1和VP2的基因。在过去10年里，在非人类灵长类动物和人类中发现了几种新型多瘤病毒。本综述比较了已完全测序的非人类灵长类多瘤病毒基因组之间以及与人类多瘤病毒基因组的差异。我们预测了蛋白质编码序列和微小RNA编码序列的存在。我们的分析表明，存在几个遗传上不同的非人类灵长类多瘤病毒组，不同的多瘤病毒可以感染同一非人类灵长类物种，但它们的大多数蛋白质显示出高度相似的结构域和基序，表明关键功能具有保守性。
