Gutiérrez C, Tamarit A, González-Martín M, Tejedor-Junco M T
Department of Animal Medicine and Surgery, Veterinary Faculty, University of Las Palmas de Gran Canaria, 35416 Arucas, Las Palmas, Canary Islands, Spain.
Animal Health Laboratory, Conselleria of Agriculture, Fishing and Nourishment, Av. Manuel Soto 18, 46024 Valencia, Spain.
Vet Parasitol. 2014 Aug 29;204(3-4):153-7. doi: 10.1016/j.vetpar.2014.05.004. Epub 2014 May 17.
In 2008, Trypanosoma evansi was detected on a camel farm in mainland Spain. The animals were isolated, confined in a closed stable, and treated twice with melarsamine (Cymelarsan(®), Merial, Lyon, France) with an interval of 1 month. Clinical and laboratory examinations by means of parasitological, serological, and molecular procedures (polymerase chain reaction (PCR)) were carried out regularly for 6 years. After the treatment, all parasitemic camels were cleared of parasites, and in the seropositive camels a progressive decrease in antibody levels was observed, with complete disappearance of antibodies between 15 and 21 months, except in one animal which showed doubtful Ag-Ab reaction at 21 months post treatment. In the next assessment, 6 months later, the diagnostic tests conducted on all animals had a negative result. The diagnostic and therapeutic tools recently developed against T. evansi will evidence new and alternative approaches after the parasite is detected, particularly if outbreak occurs in geographically localized areas in territories free of the disease.
2008年，在西班牙大陆的一个骆驼养殖场检测到伊氏锥虫。这些动物被隔离，关在一个封闭的畜栏里，并用美拉胂醇（Cymelarsan(®)，梅里亚公司，法国里昂）进行了两次治疗，间隔为1个月。通过寄生虫学、血清学和分子程序（聚合酶链反应（PCR））进行临床和实验室检查，持续了6年。治疗后，所有出现寄生虫血症的骆驼体内的寄生虫被清除，在血清阳性的骆驼中，观察到抗体水平逐渐下降，在15至21个月之间抗体完全消失，但有一只动物在治疗后21个月时出现了可疑的抗原-抗体反应。在6个月后的下一次评估中，对所有动物进行的诊断测试结果均为阴性。最近开发的针对伊氏锥虫的诊断和治疗工具将为在检测到寄生虫后提供新的替代方法，特别是如果疫情发生在无该病地区的地理局部区域。
