Hadfield J W, Windebank W J, Bateman J R
Br J Dis Chest. 1986 Jan;80(1):50-4. doi: 10.1016/0007-0971(86)90009-4.
Ten patients with stable asthma were studied to see whether the flow rate used to drive a nebulizer was clinically important. Each received 1 mg of salbutamol in 2 ml of physiological saline via a Sandoz 'Lifeline' nebulizer driven by piped oxygen at 8, 6 and 4 litres/min on separate randomly allocated occasions. Although the time for nebulization was significantly longer as flow rate was reduced, there was no significant difference in the bronchodilator response.
