Hofman P, Knol R G, Lagendijk J J, Schipper J
Department of Radiotherapy, University Hospital, Utrecht, The Netherlands.
Int J Hyperthermia. 1989 Jan-Feb;5(1):1-11. doi: 10.3109/02656738909140428.
Since 1981, 40 patients with advanced breast carcinoma have been treated with megavoltage radiotherapy combined with hyperthermia. The irradiation dose to the primary tumour was 50 Gy/25 fractions, five fractions per week. Hyperthermia (aim: 44 degrees C/30 min) was applied once a week, 30 minutes after the midweek radiation fraction. Tumour response did not correlate with the chance of long-term local control. The likelihood of 3-year local control was 46 per cent and 3-year survival was 52 per cent. The local tumour control rate decreased with increasing T stage and was related to non-uniformity of the temperature distribution in the heated volume. It was concluded that (a) the radiation dose should be increased and (b) the temperature uniformity should be improved.
自1981年以来，40例晚期乳腺癌患者接受了兆伏级放疗联合热疗。原发肿瘤的照射剂量为50 Gy/25次分割，每周5次分割。热疗（目标：44摄氏度/30分钟）每周进行一次，在周三放疗分割后30分钟进行。肿瘤反应与长期局部控制的可能性无关。3年局部控制率为46%，3年生存率为52%。局部肿瘤控制率随T分期增加而降低，且与加热体积内温度分布不均匀有关。得出的结论是：(a)应增加放射剂量；(b)应提高温度均匀性。
