Masunaga S, Hiraoka M, Takahashi M, Jo S, Akuta K, Nishimura Y, Nagata Y, Abe M
Department of Radiology, Faculty of Medicine, Kyoto University, Japan.
Int J Hyperthermia. 1990 May-Jun;6(3):487-97. doi: 10.3109/02656739009140945.
From August 1979 until 1988, 26 breast cancer patients with 30 tumours were treated by hyperthermia in combination with radiotherapy. Of the 30 tumours, 11 were locally advanced primary tumours (group 1), six were locally advanced recurrent tumours after operation (group 2) and 13 were locally recurrent tumours after radiotherapy (group 3). The thermal profiles showed that the capability of an RF capacitive heating device is comparatively high for large breast tumours with a volume of more than 100 cm3, and that of a 430 MHz microwave device with a single-lens applicator is excellent for localized tumours. The response rate of group 1 and 2 tumours was excellent, and superior to that of historically controlled tumours that were treated by radiotherapy alone from July 1962 until August 1979. In group 3 the tumour response to thermoradiotherapy was not different from that to radiotherapy, but the possibility of significantly reducing total irradiation dose was indicated. More than one good heating session led to a significantly high local response, and factors having a tendency to influence local response were average minimum tumour temperature, tumour volume, and number of effective heat treatments.
1979年8月至1988年期间，26例乳腺癌患者的30个肿瘤接受了热疗联合放疗。在这30个肿瘤中，11个为局部晚期原发性肿瘤（第1组），6个为术后局部晚期复发性肿瘤（第2组），13个为放疗后局部复发性肿瘤（第3组）。热分布图显示，对于体积超过100 cm³ 的大乳腺肿瘤，射频电容加热设备的加热能力相对较高，而对于局限性肿瘤，带有单透镜 applicator 的430 MHz 微波设备的加热能力极佳。第1组和第2组肿瘤的缓解率极佳，且优于1962年7月至1979年8月期间仅接受放疗的历史对照肿瘤。在第3组中，肿瘤对热放疗的反应与对放疗的反应无差异，但显示出显著降低总照射剂量的可能性。超过一次良好的加热疗程导致显著较高的局部反应，且倾向于影响局部反应的因素有平均最低肿瘤温度、肿瘤体积和有效热疗次数。
