Almeida Henrique A, Bártolo Paulo J
Centre for Rapid and Sustainable Product Development, School of Technology and Management, Polytechnic Institute of Leiria, Portugal.
Centre for Rapid and Sustainable Product Development, Polytechnic Institute of Leiria, Portugal Manchester Biomanufacturing Centre, School of Mechanical, Aerospace and Civil Engineering, Manchester Institute of Biotechnology, University of Manchester, UK.
Med Eng Phys. 2014 Aug;36(8):1033-40. doi: 10.1016/j.medengphy.2014.05.006. Epub 2014 Jun 13.
Tissue engineering represents a new field aiming at developing biological substitutes to restore, maintain, or improve tissue functions. In this approach, scaffolds provide a temporary mechanical and vascular support for tissue regeneration while tissue in-growth is being formed. These scaffolds must be biocompatible, biodegradable, with appropriate porosity, pore structure and distribution, and optimal vascularization with both surface and structural compatibility. The challenge is to establish a proper balance between porosity and mechanical performance of scaffolds. This work investigates the use of two different types of triple periodic minimal surfaces, Schwarz and Schoen, in order to design better biomimetic scaffolds with high surface-to-volume ratio, high porosity and good mechanical properties. The mechanical behaviour of these structures is assessed through the finite element method software Abaqus. The effect of two parametric parameters (thickness and surface radius) is also evaluated regarding its porosity and mechanical behaviour.
组织工程学是一个旨在开发生物替代物以恢复、维持或改善组织功能的新领域。在这种方法中，支架为组织再生提供临时的机械和血管支持，同时形成组织向内生长。这些支架必须具有生物相容性、可生物降解性，具有适当的孔隙率、孔结构和分布，以及具有表面和结构相容性的最佳血管化。挑战在于在支架的孔隙率和机械性能之间建立适当的平衡。这项工作研究了两种不同类型的三重周期极小曲面，即施瓦茨曲面和舍恩曲面，以便设计出具有高表面积与体积比、高孔隙率和良好机械性能的更好的仿生支架。通过有限元方法软件Abaqus评估这些结构的力学行为。还评估了两个参数（厚度和表面半径）对其孔隙率和力学行为的影响。
