Turner Michelle C, Benke Geza, Bowman Joseph D, Figuerola Jordi, Fleming Sarah, Hours Martine, Kincl Laurel, Krewski Daniel, McLean Dave, Parent Marie-Elise, Richardson Lesley, Sadetzki Siegal, Schlaefer Klaus, Schlehofer Brigitte, Schüz Joachim, Siemiatycki Jack, van Tongeren Martie, Cardis Elisabeth
Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain. Universitat Pompeu Fabra (UPF), Barcelona, Spain. CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain. McLaughlin Centre for Population Health Risk Assessment, Institute of Population Health, University of Ottawa, Ottawa, Canada.
Monash University, Melbourne, Australia.
Cancer Epidemiol Biomarkers Prev. 2014 Sep;23(9):1863-72. doi: 10.1158/1055-9965.EPI-14-0102. Epub 2014 Jun 16.
Occupational exposure to extremely low-frequency magnetic fields (ELF) is a suspected risk factor for brain tumors, however the literature is inconsistent. Few studies have assessed whether ELF in different time windows of exposure may be associated with specific histologic types of brain tumors. This study examines the association between ELF and brain tumors in the large-scale INTEROCC study.
Cases of adult primary glioma and meningioma were recruited in seven countries (Australia, Canada, France, Germany, Israel, New Zealand, and the United Kingdom) between 2000 and 2004. Estimates of mean workday ELF exposure based on a job exposure matrix were assigned. Estimates of cumulative exposure, average exposure, maximum exposure, and exposure duration were calculated for the lifetime, and 1 to 4, 5 to 9, and 10+ years before the diagnosis/reference date.
There were 3,761 included brain tumor cases (1,939 glioma and 1,822 meningioma) and 5,404 population controls. There was no association between lifetime cumulative ELF exposure and glioma or meningioma risk. However, there were positive associations between cumulative ELF 1 to 4 years before the diagnosis/reference date and glioma [odds ratio (OR) ≥ 90th percentile vs. < 25th percentile, 1.67; 95% confidence interval (CI), 1.36-2.07; PLinear trend < 0.0001], and, somewhat weaker associations with meningioma (OR ≥ 90th percentile vs. < 25th percentile, 1.23; 95% CI, 0.97-1.57; PLinear trend = 0.02).
Results showed positive associations between ELF in the recent past and glioma.
Occupational ELF exposure may play a role in the later stages (promotion and progression) of brain tumorigenesis.
职业性接触极低频磁场（ELF）被怀疑是脑肿瘤的一个风险因素，然而相关文献并不一致。很少有研究评估不同暴露时间窗内的ELF是否可能与特定组织学类型的脑肿瘤相关。本研究在大规模INTEROCC研究中考察ELF与脑肿瘤之间的关联。
2000年至2004年间在七个国家（澳大利亚、加拿大、法国、德国、以色列、新西兰和英国）招募成年原发性胶质瘤和脑膜瘤病例。根据工作暴露矩阵分配工作日平均ELF暴露估计值。计算了一生以及诊断/参考日期前1至4年、5至9年和10年以上的累积暴露、平均暴露、最大暴露和暴露持续时间估计值。
纳入3761例脑肿瘤病例（1939例胶质瘤和1822例脑膜瘤）以及5404例人群对照。一生累积ELF暴露与胶质瘤或脑膜瘤风险之间无关联。然而，诊断/参考日期前1至4年的累积ELF与胶质瘤之间存在正相关[优势比（OR）≥第90百分位数 vs.＜第25百分位数，1.67；95%置信区间（CI），1.36 - 2.07；线性趋势P＜0.0001]，与脑膜瘤的关联稍弱（OR≥第90百分位数 vs.＜第25百分位数，1.23；95%CI, 0.97 - 1.57；线性趋势P = 0.02）。
结果显示近期ELF与胶质瘤之间存在正相关。
职业性ELF暴露可能在脑肿瘤发生的后期阶段（促进和进展）起作用。
