Abuhanoğlu Gürhan, Ozer A Yekta
Department of Radiopharmacy, Faculty of Pharmacy, Hacettepe University Sıhhiye, Ankara Turkey.
Interv Med Appl Sci. 2014 Jun;6(2):51-60. doi: 10.1556/IMAS.6.2014.2.1. Epub 2014 Jun 4.
Radiation sterilization has now become a commonly used method for sterilization of several active ingredients in drugs or drug delivery systems containing these substances. In this context, many applications have been performed on the human products that are required to be sterile, as well as on pharmaceutical products prepared to be developed. The new drug delivery systems designed to deliver the medication to the target tissue or organ, such as microspheres, nanospheres, microemulsion, and liposomal systems, have been sterilized by gamma (γ) and beta (β) rays, and more recently, by e-beam sterilization. In this review, the sterilization of new drug delivery systems was discussed other than conventional drug delivery systems by γ irradiation.
辐射灭菌现已成为对药物中几种活性成分或含有这些物质的药物递送系统进行灭菌的常用方法。在此背景下，已对要求无菌的人类产品以及准备开发的药品进行了许多应用。旨在将药物递送至靶组织或器官的新型药物递送系统，如微球、纳米球、微乳和脂质体系统，已通过伽马（γ）射线和贝塔（β）射线进行灭菌，最近也通过电子束灭菌。在本综述中，除了传统药物递送系统外，还讨论了通过γ辐照对新型药物递送系统进行的灭菌。
