Pool Allan-Hermann, Scott Kristin
Department of Molecular and Cell Biology, and Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, United States.
Department of Molecular and Cell Biology, and Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, United States; Howard Hughes Medical Institute, 16 Barker Hall, University of California, Berkeley, Berkeley, CA 94720, United States.
Curr Opin Neurobiol. 2014 Dec;29:57-63. doi: 10.1016/j.conb.2014.05.008. Epub 2014 Jun 14.
Neuromodulators play a key role in adjusting animal behavior based on environmental cues and internal needs. Here, we review the regulation of Drosophila feeding behavior to illustrate how neuromodulators achieve behavioral plasticity. Recent studies have made rapid progress in determining molecular and cellular mechanisms that translate the metabolic needs of the fly into changes in neuroendocrine and neuromodulatory states. These neuromodulators in turn promote or inhibit discrete feeding behavioral subprograms. This review highlights the links between physiological needs, neuromodulatory states, and feeding decisions.
神经调质在根据环境线索和内部需求调整动物行为方面发挥着关键作用。在此，我们回顾果蝇进食行为的调节，以说明神经调质如何实现行为可塑性。最近的研究在确定将果蝇的代谢需求转化为神经内分泌和神经调节状态变化的分子和细胞机制方面取得了迅速进展。这些神经调质反过来促进或抑制离散的进食行为子程序。本综述强调了生理需求、神经调节状态和进食决策之间的联系。
