Fuchs Michael A, Sato Kaori, Niedzwiecki Donna, Ye Xing, Saltz Leonard B, Mayer Robert J, Mowat Rex B, Whittom Renaud, Hantel Alexander, Benson Al, Atienza Daniel, Messino Michael, Kindler Hedy, Venook Alan, Ogino Shuji, Wu Kana, Willett Walter C, Giovannucci Edward L, Meyerhardt Jeffrey A
Brown University, Providence, Rhode Island, United States of America.
Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America.
PLoS One. 2014 Jun 17;9(6):e99816. doi: 10.1371/journal.pone.0099816. eCollection 2014.
In colon cancer patients, obesity, sedentary lifestyle, and high dietary glycemic load have been associated with increased risk of cancer recurrence. High sugar-sweetened beverage intake has been associated with obesity, diabetes, and cardio-metabolic diseases, but the influence on colon cancer survival is unknown.
We assessed the association between sugar-sweetened beverage consumption on cancer recurrence and mortality in 1,011 stage III colon cancer patients who completed food frequency questionnaires as part of a U.S. National Cancer Institute-sponsored adjuvant chemotherapy trial. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated with Cox proportional hazard models.
Patients consuming ≥ 2 servings of sugar-sweetened beverages per day experienced an adjusted HR for disease recurrence or mortality of 1.67 (95% CI, 1.04-2.68), compared with those consuming <2 servings per month (P(trend) = 0.02). The association of sugar-sweetened beverages on cancer recurrence or mortality appeared greater among patients who were both overweight (body mass index ≥ 2 5 kg/m(2)) and less physically active (metabolic equivalent task-hours per week <18) (HR = 2.22; 95% CI, 1.29-3.81, P(trend) = 0.0025).
Higher sugar-sweetened beverage intake was associated with a significantly increased risk of cancer recurrence and mortality in stage III colon cancer patients.
在结肠癌患者中，肥胖、久坐不动的生活方式以及高膳食血糖负荷与癌症复发风险增加有关。高糖饮料的摄入与肥胖、糖尿病及心血管代谢疾病有关，但对结肠癌患者生存的影响尚不清楚。
我们在美国国立癌症研究所资助的辅助化疗试验中，对1011例III期结肠癌患者进行了评估，这些患者完成了食物频率问卷调查，以评估含糖饮料消费与癌症复发和死亡率之间的关联。采用Cox比例风险模型计算风险比（HR）和95%置信区间（CI）。
每天饮用≥2份含糖饮料的患者，疾病复发或死亡的校正HR为1.67（95%CI，1.04 - 2.68），而每月饮用<2份的患者为参照组（P趋势 = 0.02）。在超重（体重指数≥25kg/m²）且体力活动较少（每周代谢当量任务小时数<18）的患者中，含糖饮料与癌症复发或死亡率的关联似乎更强（HR = 2.22；95%CI，1.29 - 3.81，P趋势 = 0.0025）。
较高的含糖饮料摄入量与III期结肠癌患者癌症复发和死亡风险的显著增加有关。
