Costa Tássia R, Burin Sandra M, Menaldo Danilo L, de Castro Fabíola A, Sampaio Suely V
Department of Clinical, Toxicological and Bromatological Analysis, School of Pharmaceutical Sciences, University of São Paulo (USP), Ribeirão Preto, São Paulo State, Brazil.
Department of Clinical, Toxicological and Bromatological Analysis, School of Pharmaceutical Sciences, University of São Paulo (USP), Ribeirão Preto, São Paulo State, Brazil ; Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Avenida do Café, s/n, B. Monte Alegre, Ribeirão Preto, SP CEP 14040-903, Brasil.
J Venom Anim Toxins Incl Trop Dis. 2014 Jun 2;20:23. doi: 10.1186/1678-9199-20-23. eCollection 2014.
The L-amino acid oxidases (LAAOs) constitute a major component of snake venoms and have been widely studied due to their widespread presence and various effects, such as apoptosis induction, cytotoxicity, induction and/or inhibition of platelet aggregation, hemorrhage, hemolysis, edema, as well as antimicrobial, antiparasitic and anti-HIV activities. The isolated and characterized snake venom LAAOs have become important research targets due to their potential biotechnological applications in pursuit for new drugs of interest in the scientific and medical fields. The current study discusses the antitumor effects of snake venom LAAOs described in the literature to date, highlighting the mechanisms of apoptosis induction proposed for this class of proteins.
L-氨基酸氧化酶（LAAOs）是蛇毒的主要成分之一，由于其广泛存在及多种作用，如诱导细胞凋亡、细胞毒性、诱导和/或抑制血小板聚集、出血、溶血、水肿以及抗菌、抗寄生虫和抗HIV活性等，已得到广泛研究。由于蛇毒LAAOs在科学和医学领域寻找新型感兴趣药物方面具有潜在的生物技术应用价值，已分离和鉴定的蛇毒LAAOs成为重要的研究靶点。本研究讨论了迄今为止文献中描述的蛇毒LAAOs的抗肿瘤作用，重点介绍了这类蛋白质诱导细胞凋亡的机制。
