Sanya T E, Titilayo O F, Adisa R, Segun J S
Department of Clinical Pharmacy & Pharmacy Administration, University of Ibadan, Nigeria.
Afr Health Sci. 2013 Dec;13(4):1149-55. doi: 10.4314/ahs.v13i4.41.
Antibiotic misuse is a major contributory factor to treatment failure, antibiotic resistance and high healthcare costs.
To evaluate level of self-reported antibiotic misuse among non-medical undergraduate students of a Nigerian university.
Respondents' knowledge of antibiotics and disposal system for left-over antibiotics were explored using a structured questionnaire. Data were summarized with descriptive statistics. Chi square was used to evaluate relationship between specific categorical variables and respondents' opinions with p<0.05.
More than half the respondents obtained their antibiotics through doctor's prescriptions (273; 68.3%). The study revealed gross antibiotic misuse with majority, (298;74.5%) either by keeping left-over antibiotics for future use or throwing it away with refuse. Respondents (289; 72.3%) sometimes forgot to take the antibiotics. Financial constraints (73; 18.3%), long duration of treatment (70; 17.5%), side effects experienced (60;15.0%), polypharmacy (56;14.0%), tablet size (45;11.3%), and perceived low level of confidence in the prescriber (11; 2.8%) were major reasons for non-adherence. Course of study of respondents had no significant effect on respondents' knowledge or adherence (p>0.05).
Misuse of antibiotics among non-medical undergraduate students in a Nigerian university setting is pervasive suggesting an urgent need for enlightenment on rational use and disposal of antibiotics.
抗生素的滥用是导致治疗失败、抗生素耐药性以及高昂医疗费用的一个主要因素。
评估一所尼日利亚大学非医学专业本科生自我报告的抗生素滥用水平。
通过一份结构化问卷探究受访者对抗生素的了解以及剩余抗生素的处理方式。数据采用描述性统计进行汇总。使用卡方检验评估特定分类变量与受访者意见之间的关系，p<0.05具有统计学意义。
超过一半的受访者通过医生处方获取抗生素（273人；68.3%）。研究显示存在严重的抗生素滥用情况，大多数人（298人；74.5%）要么留存剩余抗生素以备将来使用，要么将其与垃圾一起扔掉。受访者中有289人（72.3%）有时会忘记服用抗生素。经济限制（73人；18.3%）、治疗时间长（70人；17.5%）、出现副作用（60人；15.0%）、联合用药（56人；14.0%）、药片大小（45人；11.3%）以及对开处方者的信心不足（11人；2.8%）是不遵医嘱的主要原因。受访者的专业课程对其知识水平或遵医嘱情况没有显著影响（p>0.05）。
在尼日利亚大学环境中，非医学专业本科生抗生素滥用现象普遍，这表明迫切需要开展关于抗生素合理使用和处置的宣传教育。
