Tan Aaron, Farhatnia Yasmin, Seifalian Alexander M
Centre for Nanotechnology and Regenerative Medicine, Division of Surgery and Interventional Science, University College London, London, UK.
Centre for Nanotechnology and Regenerative Medicine, Division of Surgery and Interventional Science, University College London, UK; Royal Free London National Health Service Foundation Trust Hospital, London, UK.
Crit Rev Biomed Eng. 2013;41(6):495-513.
The field of nanotechnology and regenerative medicine has been progressing at a rapid pace. From theranostic nanoparticles to biomaterials, the possibilities seem endless. Researchers at the University College London have developed and patented a technology to manufacture a new breed of novel nanocomposite material called polyhedral oligomeric silsesquioxane poly(carbonate-urea) urethane (POSS-PCU). The enhanced biocompatibility, superior mechanical engineering properties, and augmented degradative resistance of POSS-PCU render it capable of functioning as a scaffold for bioartificial organs, nanoparticles for biomedical applications, and a coating for medical devices. Indeed, POSS-PCU has been used in 3 first-in-man studies as a bypass graft, lacrimal duct, and, most notably, the world's first synthetic trachea. Our group has a vested interest in the development of next-generation smart biomaterials that use nano-inspired technologies and mobilize the regenerative capacity of biological systems. Herein we provide a concise and authoritative account of the evolution of biomaterials research within a University College London and POSS-PCU context, with further emphasis on the prospects and challenges involved in driving the future of bioartificial organs in tandem with advanced drug delivery systems in the realm of nanotechnology and regenerative medicine.
纳米技术与再生医学领域一直在飞速发展。从诊疗纳米颗粒到生物材料，可能性似乎无穷无尽。伦敦大学学院的研究人员已研发出一项技术并获得专利，用于制造一种名为多面体低聚倍半硅氧烷聚（碳酸酯 - 脲）聚氨酯（POSS - PCU）的新型纳米复合材料。POSS - PCU增强的生物相容性、卓越的机械工程性能以及更强的抗降解性使其能够用作生物人工器官的支架、生物医学应用的纳米颗粒以及医疗设备的涂层。事实上，POSS - PCU已在三项首例人体研究中用作旁路移植物、泪道，最值得注意的是，它还被用于制造世界上第一个合成气管。我们团队对开发利用纳米启发技术并调动生物系统再生能力的下一代智能生物材料有着浓厚兴趣。在此，我们在伦敦大学学院及POSS - PCU的背景下，对生物材料研究的发展进行了简洁而权威的阐述，并进一步强调了在纳米技术和再生医学领域，与先进药物递送系统协同推动生物人工器官未来发展所涉及的前景与挑战。
