Departamento de Análises Clínicas, Faculdade de Ciências Farmacêuticas de Araraquara, UNESP, Universidade Estadual Paulista, Araraquara-SP, 14801-902, Brazil.
Departamento de Cosmetologia, Faculdade de Ciências Farmacêuticas de Araraquara, UNESP, Universidade Estadual Paulista, Araraquara-SP, 14801-902, Brazil.
Molecules. 2014 Jun 17;19(6):8124-39. doi: 10.3390/molecules19068124.
Ethyl ferulate (FAEE) has been widely studied due to its beneficial heath properties and, when incorporated in creams, shows a high sun protection capacity. Here we aimed to compare FAEE and its precursor, ferulic acid (FA), as free radical scavengers, inhibitors of oxidants produced by leukocytes and the alterations in rheological properties when incorporated in emulsion based creams. The cell-free antiradical capacity of FAEE was decreased compared to FA. However, FAEE was more effective regarding the scavenging of reactive oxygen species produced by activated leukocytes. Stress and frequency sweep tests showed that the formulations are more elastic than viscous. The viscoelastic features of the formulations were confirmed in the creep and recovery assay and showed that the FAEE formulation was less susceptive to deformation. Liberation experiments showed that the rate of FAEE release from the emulsion was slower compared to FA. In conclusion, FAEE is more effective than FA as a potential inhibitor of oxidative damage produced by oxidants generated by leukocytes. The rheological alterations caused by the addition of FAEE are indicative of lower spreadability, which could be useful for formulations used in restricted areas of the skin.
阿魏酸乙酯（FAEE）因其有益的健康特性而被广泛研究，当它被添加到乳膏中时，显示出很高的防晒能力。在这里，我们旨在比较 FAEE 和它的前体阿魏酸（FA）作为自由基清除剂，抑制白细胞产生的氧化剂以及在乳液基乳膏中加入时流变性质的变化。FAEE 的无细胞抗自由基能力比 FA 低。然而，FAEE 在清除由激活的白细胞产生的活性氧方面更有效。应力和频率扫描测试表明，配方比粘性更有弹性。在蠕变和恢复试验中证实了配方的粘弹性特征，表明 FAEE 配方不易变形。释放实验表明，FAEE 从乳液中的释放速度比 FA 慢。总之，FAEE 作为由白细胞产生的氧化剂产生的氧化损伤的潜在抑制剂比 FA 更有效。FAEE 的添加引起的流变学变化表明其扩展性较低，这对于用于皮肤受限区域的制剂可能是有用的。
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