了解急性肝炎中假阳性抗体的存在情况。
Understanding the presence of false-positive antibodies in acute hepatitis.
作者信息
Sakiani Sasan, Koh Christopher, Heller Theo
机构信息
Translational Hepatology Unit, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH), Bethesda, Maryland Division of Gastroenterology and Hepatology, Metrohealth Medical Center, Case Western University, Cleveland, Ohio.
Translational Hepatology Unit, Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH), Bethesda, Maryland.
出版信息
J Infect Dis. 2014 Dec 15;210(12):1886-9. doi: 10.1093/infdis/jiu348. Epub 2014 Jun 18.
Although false-positive antibodies (FPAs) have been well described in chronic hepatitis C virus (HCV), this has not been evaluated in acute viral hepatitis. Patients with acute viral hepatitis underwent antibody testing for other causes of liver disease and sexually transmitted diseases. Those with antibody positivity underwent confirmatory testing and monitoring. Patients with FPAs were compared with patients with acute hepatitis C infection without FPAs. In total 7 of 24 patients (29%) had FPAs. FPAs during acute viral hepatitis are associated with higher IgM levels and higher ESR in acute HCV. This has both mechanistic and clinical implications and should be evaluated further.
虽然在慢性丙型肝炎病毒（HCV）感染中，假阳性抗体（FPA）已被充分描述，但在急性病毒性肝炎中尚未对此进行评估。急性病毒性肝炎患者接受了针对其他肝病病因和性传播疾病的抗体检测。抗体呈阳性的患者接受了确证检测和监测。将出现FPA的患者与未出现FPA的急性丙型肝炎感染患者进行了比较。24例患者中有7例（29%）出现FPA。急性病毒性肝炎期间的FPA与急性丙型肝炎中较高的IgM水平和较高的红细胞沉降率（ESR）相关。这具有机制和临床方面的意义，应进一步评估。
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