Oreh Adaeze, Biyama Felix, Bozegha Tariere, Fapohunda Joshua, Mgbachi Ifeanyi, Dalyop Victoria, Elisha Joy, Olupitan Folashade, Isaiah Audu, Babalola Catherine, Malammadori Abdullahi, Agahiu Emmanuel, Kure Deborah, Imonikhe Caroline, Elesie Chinonso, Ogedegbe Ajoke E, Omokaro Ukinebo, Egbeaso Jerry, Oparah Chika, Amedu Omale, Postma Maarten, Nwagha Theresa, van Hulst Marinus
Department of Planning, Research and Statistics, National Blood Service Agency, Abuja, Nigeria.
Department of Health Sciences, University Medical Centre Groningen, Groningen, Netherlands.
Transfus Med. 2025 Aug;35(4):374-384. doi: 10.1111/tme.13160. Epub 2025 Jul 7.
Blood transfusion's life-saving potential is often marred by the risks of transfusion-transmissible infections (TTIs) from blood donors, for which sub-Saharan African countries record some of the highest burdens.
We aimed to assess the seroprevalence of HBV, HCV, HIV, and Treponema pallidum among blood donors in Nigeria, and determine the association of seropositivity with particular blood donor characteristics.
A retrospective cross-sectional study was conducted to determine the seroprevalence of HBV, HCV, HIV, and Treponema pallidum among blood donors in 13 blood establishments in Nigeria's six geopolitical zones from January 2018 to December 2019 following screening with highly sensitive Enzyme-Linked Immunosorbent Assays. Data was collected from the country's web-based software District Health Information System, Version 2 and analysed using R Studio.
The overall TTI seroprevalence was 10.1%, and declined from 10.9% in 2018 to 9.4% in 2019. Male donors (AOR = 0.1; 95% CI: 0.1-0.2, p < 0.001), those aged 46-55 years (AOR = 0.8, 95% CI: 0.7-0.9, p < 0.001), and first-time donors (AOR = 0.1, 95% CI: 0.10-0.12, p < 0.001) were less likely to be seropositive; whereas paid donors (AOR = 2.3, 95% CI: 2.1-2.6, p < 0.001) and mobile blood drive donors (AOR = 1.4; 95% CI: 1.3-1.5, p < 0.001) were more likely to be seropositive.
The seroprevalence of TTIs in Nigerian blood donors is high, especially among females, paid donors, and those at mobile donation sites, emphasising the importance of targeted continuous population health education and quality donor selection towards enhancing blood safety.
输血挽救生命的潜力常常因献血者感染输血传播感染（TTIs）的风险而受到影响，撒哈拉以南非洲国家的此类负担尤为严重。
我们旨在评估尼日利亚献血者中乙肝病毒（HBV）、丙肝病毒（HCV）、人类免疫缺陷病毒（HIV）和梅毒螺旋体的血清流行率，并确定血清阳性与特定献血者特征之间的关联。
进行了一项回顾性横断面研究，以确定2018年1月至2019年12月期间尼日利亚六个地缘政治区13个采血机构的献血者中HBV、HCV、HIV和梅毒螺旋体的血清流行率，采用高灵敏度酶联免疫吸附试验进行筛查。数据从该国基于网络的软件地区卫生信息系统第2版收集，并使用R Studio进行分析。
总体TTIs血清流行率为10.1%，从2018年的10.9%降至2019年的9.4%。男性献血者（调整后比值比[AOR]=0.1；95%置信区间[CI]：0.1 - 0.2，p<0.001）、年龄在46 - 55岁的献血者（AOR = 0.8，95% CI：0.7 - 0.9，p<0.001）和首次献血者（AOR = 0.1，95% CI：0.10 - 0.12，p<0.001）血清阳性的可能性较小；而有偿献血者（AOR = 2.3，95% CI：2.1 - 2.6，p<0.001）和流动献血活动的献血者（AOR = 1.4；95% CI：1.3 - 1.5，p<0.001）血清阳性的可能性较大。
尼日利亚献血者中TTIs的血清流行率较高，尤其是在女性、有偿献血者和流动献血点的献血者中，这凸显了有针对性地持续开展人群健康教育和进行高质量献血者选择对于提高血液安全的重要性。
