内禀锗-69标记的氧化铁纳米颗粒：合成及体内双模态PET/MR成像
Intrinsically germanium-69-labeled iron oxide nanoparticles: synthesis and in-vivo dual-modality PET/MR imaging.
作者信息
Chakravarty Rubel, Valdovinos Hector F, Chen Feng, Lewis Christina M, Ellison Paul A, Luo Haiming, Meyerand M Elizabeth, Nickles Robert J, Cai Weibo
机构信息
Department of Radiology, University of Wisconsin - Madison, Madison, WI, USA; Isotope Applications and Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai, India.
出版信息
Adv Mater. 2014 Aug 13;26(30):5119-23. doi: 10.1002/adma.201401372. Epub 2014 Jun 18.
Abstract
Intrinsically germanium-69-labeled super-paramagnetic iron oxide nanoparticles are synthesized via a newly developed, fast and highly specific chelator-free approach. The biodistribution pattern and the feasibility of (69) Ge-SPION@PEG for in vivo dual-modality positron emission tomography/magnetic resonance (PET/MR) imaging and lymph-node mapping are investigated, which represents the first example of the successful utilization of a (69) Ge-based agent for PET/MR imaging.
摘要
通过一种新开发的、快速且高度特异性的无螯合剂方法合成了具有内在69锗标记的超顺磁性氧化铁纳米颗粒。研究了69Ge-SPION@PEG在体内双模态正电子发射断层扫描/磁共振（PET/MR）成像和淋巴结定位中的生物分布模式及可行性，这代表了成功利用基于69锗的试剂进行PET/MR成像的首个实例。
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