HIV/乙型肝炎病毒（HBV）/丙型肝炎病毒（HCV）三重感染患者与HIV/HCV合并感染患者的肝失代偿情况及抗HBV核苷（酸）类似物治疗的效果
Hepatic decompensation in patients with HIV/Hepatitis B Virus (HBV)/Hepatitis C Virus (HCV) triple infection versus HIV/HCV coinfection and the effect of anti-HBV nucleos(t)ide therapy.
作者信息
Lo Re Vincent, Wang Li, Devine Scott, Baser Onur, Olufade Temitope
机构信息
Department of Medicine and Penn Center for AIDS Research Department of Biostatistics and Epidemiology and Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania and Philadelphia VA Medical Center, Philadelphia, Pennsylvania.
Analytic Research, STATinMED Research, Dallas, Texas.
出版信息
Clin Infect Dis. 2014 Oct;59(7):1027-31. doi: 10.1093/cid/ciu476. Epub 2014 Jun 18.
Abstract
The incidence rate of hepatic decompensation was higher in patients with human immunodeficiency virus (HIV)/hepatitis B virus (HBV)/hepatitis C virus (HCV) triple infection than in those with HIV/HCV coinfection (24.1 vs 10.8 events per 1000 person-years; hazard ratio [HR], 1.89; 95% confidence interval [CI], 1.12-3.18). Compared with HIV/HCV-infected patients, the rate of decompensation was increased among HIV/HBV/HCV-infected patients receiving no anti-HBV therapy (HR, 2.48; 95% CI, 1.37-4.49) but not among those who did receive such therapy (HR, 1.09; 95% CI, .40-2.97).
摘要
人类免疫缺陷病毒（HIV）/乙型肝炎病毒（HBV）/丙型肝炎病毒（HCV）三重感染患者的肝失代偿发生率高于HIV/HCV合并感染患者（分别为每1000人年24.1次事件和10.8次事件；风险比[HR]为1.89；95%置信区间[CI]为1.12 - 3.18）。与HIV/HCV感染患者相比，未接受抗HBV治疗的HIV/HBV/HCV感染患者的失代偿率升高（HR为2.48；95%CI为1.37 - 4.49），但接受此类治疗的患者中失代偿率未升高（HR为1.09；95%CI为0.40 - 2.97）。
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