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本文引用的文献

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Hepatic decompensation in antiretroviral-treated patients co-infected with HIV and hepatitis C virus compared with hepatitis C virus-monoinfected patients: a cohort study.抗逆转录病毒治疗的 HIV 和丙型肝炎病毒合并感染患者与丙型肝炎病毒单感染患者的肝失代偿比较：一项队列研究。
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Prevalence of diagnosed chronic hepatitis B infection among U.S. Medicaid enrollees, 2000-2007.2000 - 2007年美国医疗补助计划参保者中确诊慢性乙型肝炎感染的患病率。
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Antiretroviral treatment of adult HIV infection: 2012 recommendations of the International Antiviral Society-USA panel.成人 HIV 感染的抗逆转录病毒治疗：美国国际抗病毒学会 2012 年推荐意见。
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Relationship of liver disease stage and antiviral therapy with liver-related events and death in adults coinfected with HIV/HCV.成人 HIV/HCV 合并感染患者的肝病分期和抗病毒治疗与肝脏相关事件和死亡的关系。
JAMA. 2012 Jul 25;308(4):370-8. doi: 10.1001/jama.2012.7844.
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Validity of diagnostic codes and liver-related laboratory abnormalities to identify hepatic decompensation events in the Veterans Aging Cohort Study.诊断代码和与肝脏相关的实验室异常在退伍军人老龄化队列研究中识别肝失代偿事件的有效性。
Pharmacoepidemiol Drug Saf. 2011 Jul;20(7):689-99. doi: 10.1002/pds.2148. Epub 2011 May 27.
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Clinical and virological outcomes in HIV-infected patients with chronic hepatitis B on long-term nucleos(t)ide analogues.慢性乙型肝炎病毒感染的 HIV 患者长期使用核苷（酸）类似物的临床和病毒学结局。
AIDS. 2011 Jan 2;25(1):73-9. doi: 10.1097/QAD.0b013e328340fde2.
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Longitudinal evaluation of viral interactions in treated HIV-hepatitis B co-infected patients with additional hepatitis C and D virus.治疗后 HIV-乙型肝炎合并丙型和丁型肝炎病毒感染患者中病毒相互作用的纵向评估。
J Viral Hepat. 2010 Jan;17(1):65-76. doi: 10.1111/j.1365-2893.2009.01153.x. Epub 2009 Aug 4.
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Viral interference between hepatitis B, C, and D viruses in dual and triple infections in HIV-positive patients.HIV阳性患者中乙型、丙型和丁型肝炎病毒双重及三重感染时的病毒相互干扰
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Sustained virological response to interferon plus ribavirin reduces liver-related complications and mortality in patients coinfected with human immunodeficiency virus and hepatitis C virus.对干扰素加利巴韦林的持续病毒学应答可降低人类免疫缺陷病毒和丙型肝炎病毒合并感染患者的肝脏相关并发症及死亡率。
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Co-infection of hepatitis B and hepatitis C virus in human immunodeficiency virus-infected patients in New York City, United States.美国纽约市人类免疫缺陷病毒感染患者中乙型肝炎和丙型肝炎病毒的合并感染
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HIV/乙型肝炎病毒（HBV）/丙型肝炎病毒（HCV）三重感染患者与HIV/HCV合并感染患者的肝失代偿情况及抗HBV核苷（酸）类似物治疗的效果

Hepatic decompensation in patients with HIV/Hepatitis B Virus (HBV)/Hepatitis C Virus (HCV) triple infection versus HIV/HCV coinfection and the effect of anti-HBV nucleos(t)ide therapy.

作者信息

Lo Re Vincent, Wang Li, Devine Scott, Baser Onur, Olufade Temitope

机构信息

Department of Medicine and Penn Center for AIDS Research Department of Biostatistics and Epidemiology and Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania and Philadelphia VA Medical Center, Philadelphia, Pennsylvania.

Analytic Research, STATinMED Research, Dallas, Texas.

出版信息

Clin Infect Dis. 2014 Oct;59(7):1027-31. doi: 10.1093/cid/ciu476. Epub 2014 Jun 18.

DOI:10.1093/cid/ciu476
PMID:24944235
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6284256/
Abstract

The incidence rate of hepatic decompensation was higher in patients with human immunodeficiency virus (HIV)/hepatitis B virus (HBV)/hepatitis C virus (HCV) triple infection than in those with HIV/HCV coinfection (24.1 vs 10.8 events per 1000 person-years; hazard ratio [HR], 1.89; 95% confidence interval [CI], 1.12-3.18). Compared with HIV/HCV-infected patients, the rate of decompensation was increased among HIV/HBV/HCV-infected patients receiving no anti-HBV therapy (HR, 2.48; 95% CI, 1.37-4.49) but not among those who did receive such therapy (HR, 1.09; 95% CI, .40-2.97).

摘要

人类免疫缺陷病毒（HIV）/乙型肝炎病毒（HBV）/丙型肝炎病毒（HCV）三重感染患者的肝失代偿发生率高于HIV/HCV合并感染患者（分别为每1000人年24.1次事件和10.8次事件；风险比[HR]为1.89；95%置信区间[CI]为1.12 - 3.18）。与HIV/HCV感染患者相比，未接受抗HBV治疗的HIV/HBV/HCV感染患者的失代偿率升高（HR为2.48；95%CI为1.37 - 4.49），但接受此类治疗的患者中失代偿率未升高（HR为1.09；95%CI为0.40 - 2.97）。