Yu Guangcai, Kan Baotian, Jian Xiangdong, Wang Jieru, Sun Jing, Song Chengzhen
Department of Poisoning and Occupational Diseases, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China.
Exp Ther Med. 2014 Jul;8(1):233-236. doi: 10.3892/etm.2014.1727. Epub 2014 May 20.
In the present study, the successful management of severe paraquat (PQ) poisoning with multiple organ dysfunction syndrome is described. A 42-year-old female ingested >100 ml PQ (20% weight/volume) in an attempted suicide. After 22 h the patient was admitted to hospital with serious liver, kidney and lung damage. Comprehensive therapy that maximized poison elimination was administered, along with appropriate glucocorticoids and medication for anticoagulation and protection of the liver and kidney. The patient was successfully treated and recovered after 40 days. However, pulmonary damage was aggravated when the glucocorticoid treatment was stopped after 2 months; the lungs recovered again following systematic therapy. Subsequent to a 8-month follow-up, the patient was able to look after herself in her daily life. To the best of our knowledge, successful treatment following severe PQ poisoning is rare.
本研究描述了对伴有多器官功能障碍综合征的严重百草枯（PQ）中毒的成功治疗。一名42岁女性为自杀企图摄入了超过100毫升的PQ（20%重量/体积）。22小时后，该患者因严重的肝、肾和肺损伤入院。给予了最大限度清除毒物的综合治疗，以及适当的糖皮质激素和抗凝及保护肝肾的药物。患者在40天后成功治愈并康复。然而，2个月后停止糖皮质激素治疗时肺损伤加重；经系统治疗后肺部再次恢复。经过8个月的随访，患者在日常生活中能够自理。据我们所知，严重PQ中毒后的成功治疗很少见。
