Manfredini Roberto, Fabbian Fabio, Giorgi Alfredo De, Pala Marco, Menegatti Alessandra Mallozzi, Parisi Claudia, Misurati Elisa, Tiseo Ruana, Gallerani Massimo, Salmi Raffaella, Bossone Eduardo
Roberto Manfredini , Fabio Fabbian, Alfredo De Giorgi, Marco Pala, Alessandra Mallozzi Menegatti, Claudia Parisi, Elisa Misurati, Ruana Tiseo, Clinica Medica, Azienda Ospedaliera-Universitaria of Ferrara, 44124 Cona, Ferrara, Italy.
World J Cardiol. 2014 May 26;6(5):338-44. doi: 10.4330/wjc.v6.i5.338.
To investigate the possible association between Tako-tsubo cardiomyopathy (TTC)-a reversible clinical condition mimicking an acute myocardial infarction characterized by multifactorial pathophysiologic mechanisms- and respiratory system diseases.
We systematically searched PubMed and EMBASE medical information sources, to identify the different triggering causes, limiting our search to articles in English. The search keywords were: "tako-tsubo cardiomyopathy", "takotsubo", "takotsubo cardiomyopathy", "broken heart syndrome", "stress-induced cardiomyopathy", "apical ballooning syndrome", and "ampulla cardiomyopathy in combination with respiratory diseases, lung, pulmonary disease. For each kind of disease, we registered: author, year and country of study, patient sex, age, concurring situation, and outcome.
Out of a total of 1725 articles found, we selected 37 papers reporting a total of 38 patients. As expected, most patients were women (81.6%), mean age was 65 ± 10 years. Outcome was favorable in 100% of cases, and all the patients have been discharged uneventfully in a few days.
An association between respiratory diseases and TTC is likely to exist. Patients with severe respiratory diseases, due to the high dosages of β2-agonists used or to the need of invasive procedures, are highly exposed to the risk of developing TTC.
探讨应激性心肌病（TTC）——一种以多因素病理生理机制为特征的、类似急性心肌梗死的可逆性临床病症——与呼吸系统疾病之间可能存在的关联。
我们系统检索了PubMed和EMBASE医学信息源，以确定不同的触发原因，并将检索范围限定为英文文章。检索关键词为：“应激性心肌病”“章鱼壶心肌病”“应激性心肌病”“心碎综合征”“应激性心肌病”“心尖气球样综合征”以及“壶腹心肌病与呼吸系统疾病、肺、肺部疾病”。对于每种疾病，我们记录了：作者、研究年份和国家、患者性别、年龄、并发情况及结果。
在总共找到的1725篇文章中，我们选择了37篇报告，共涉及38例患者。正如预期的那样，大多数患者为女性（81.6%），平均年龄为65±10岁。所有病例的结果均良好，所有患者均在数天内顺利出院。
呼吸系统疾病与TTC之间可能存在关联。患有严重呼吸系统疾病的患者，由于使用高剂量的β2激动剂或需要进行侵入性操作，极易面临发生TTC的风险。
