Zhu Jin-Zhou, Yu Chao-Hui, Li You-Ming
Department of Gastroenterology and Hepatology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China.
Biomed Rep. 2014 Jul;2(4):447-451. doi: 10.3892/br.2014.284. Epub 2014 May 20.
Replenishing the insulin-producing β-cell mass is considered to be a potential cure for diabetes. A recent study identified a secreted protein, known as betatrophin, which potently induces pancreatic β-cell proliferation. Notably, a number of studies reportedly identified betatrophin, which is also known as lipasin, atypical angiopoietin-like 8 and refeeding-induced fat and liver protein, and considered to be a novel regulator in lipid metabolism according to the studies. The identification of betatrophin was considered to create novel opportunities for potential diabetes therapy. In the present study, the current knowledge of betatrophin is reviewed, with regards to its character and function in lipid homeostasis and pancreatic β-cell proliferation.
补充产生胰岛素的β细胞数量被认为是治疗糖尿病的一种潜在方法。最近的一项研究发现了一种分泌蛋白，称为β细胞营养因子，它能有效地诱导胰腺β细胞增殖。值得注意的是，据报道多项研究发现了β细胞营养因子，它也被称为脂肪抑制素、非典型血管生成素样8和再喂养诱导的脂肪和肝脏蛋白，并且根据这些研究被认为是脂质代谢中的一种新型调节因子。β细胞营养因子的发现被认为为潜在的糖尿病治疗创造了新的机会。在本研究中，我们回顾了关于β细胞营养因子在脂质稳态和胰腺β细胞增殖方面的特性和功能的当前知识。
