Tan Hong-Yu, Wang Li-Min, Zhao Liang, Liu Yi-Lin, Song Rui-Peng
Pain Res Manag. 2015 Jan-Feb;20(1):e8-e11. doi: 10.1155/2015/181487. Epub 2014 Jun 19.
Percutaneous vertebroplasty (PVP) for patients with chronic painful osteoporotic compression fractures has not been extensively studied.
To prospectively evaluate the efficacy of PVP for patients with chronic painful osteoporotic vertebral compression fractures (VCFs).
Sixty-two consecutive patients with chronic painful osteoporotic VCFs for ≥3 months underwent PVP. All procedures were performed under local anesthesia. The outcomes were pain relief at one week, one month, three months, six months and one year, as measured by visual analogue scale, Oswestry Disability Index, Quality of Life Questionnaire of the European Foundation for Osteoporosis (QUALEFFO) and Roland Morris Disability Questionnaire scores.
The PVP procedures were technically successful and well tolerated in all patients. Sixty-two patients underwent PVP on 92 vertebrae in 73 procedures three to five days after referral, and no 30-day mortality was observed. Compared with baseline scores, improvement in visual analogue scale, Oswestry Disability Index, QUALEFFO and Roland Morris Disability Questionnaire scores was significantly greater after PVP at one week (P<0.001), one month (P<0.001), three months (P<0.001), six months (P<0.001) and one year (P<0.001), and the number of patients using drugs for pain treatment was significantly reduced. Five new fractures were reported in five of 62 patients treated with PVP during follow-up.
PVP is effective in patients with chronic painful osteoporotic VCFs. Pain relief after PVP was immediate, was sustained for one year and may be an important factor for reducing persistent pain.
经皮椎体成形术（PVP）治疗慢性疼痛性骨质疏松性椎体压缩骨折患者的研究尚未广泛开展。
前瞻性评估PVP治疗慢性疼痛性骨质疏松性椎体压缩骨折（VCF）患者的疗效。
连续62例慢性疼痛性骨质疏松性VCF患者，病程≥3个月，接受PVP治疗。所有手术均在局部麻醉下进行。通过视觉模拟评分、Oswestry功能障碍指数、欧洲骨质疏松症基金会生活质量问卷（QUALEFFO）和罗兰·莫里斯功能障碍问卷评分来评估1周、1个月、3个月、6个月和1年时的疼痛缓解情况。
所有患者的PVP手术在技术上均获成功，且耐受性良好。62例患者在转诊后3至5天内接受了73次手术，对92个椎体实施了PVP，未观察到30天内死亡病例。与基线评分相比，PVP术后1周（P<0.001）、1个月（P<0.001）、3个月（P<0.001）、6个月（P<0.001）和1年（P<0.001）时，视觉模拟评分、Oswestry功能障碍指数、QUALEFFO和罗兰·莫里斯功能障碍问卷评分的改善均显著更大，且使用止痛药物的患者数量显著减少。随访期间，62例接受PVP治疗的患者中有5例报告发生了5处新骨折。
PVP对慢性疼痛性骨质疏松性VCF患者有效。PVP术后疼痛立即缓解，并持续1年，可能是减轻持续性疼痛的重要因素。
