Davidson Lance E, Kelley David E, Heshka Stanley, Thornton John, Pi-Sunyer F Xavier, Boxt Lawrence, Balasubramanyam Ashok, Gallagher Dympna
New York Obesity Nutrition Research Center, St. Luke's-Roosevelt Hospital, Columbia University, New York, New York; Institute of Human Nutrition, Columbia University, New York, New York;
Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania;
J Appl Physiol (1985). 2014 Aug 15;117(4):377-82. doi: 10.1152/japplphysiol.01095.2013. Epub 2014 Jun 19.
Whether lean body mass (LBM) composition, especially skeletal muscle and abdominal organs, differs in adults with type 2 diabetes (T2DM) compared with nondiabetic healthy controls has not been investigated. A subset of African-American and Caucasian participants with T2DM from the Look AHEAD (Action for Health in Diabetes) trial had body composition assessed and compared with a sample of healthy controls. Skeletal muscle mass (SMM), liver, kidneys, and spleen mass were quantified using a contiguous slice magnetic resonance imaging (MRI) protocol. Cardiac mass was quantified by either a cardiac gated MRI protocol or by echocardiography. MRI volumes were converted to mass using assumed densities. Dual-energy X-ray absorptiometry assessed LBM. Using general linear models adjusted for height, weight, sex, age, race, and interactions of diabetes status with race or sex, persons with T2DM (n = 95) had less LBM (49.7 vs. 51.6 kg) and SMM (24.1 vs. 25.4 kg) and larger kidneys (0.40 vs. 0.36 kg) than controls (n = 76) (all P < 0.01). Caucasians with T2DM had larger livers (1.90 vs. 1.60 kg, P < 0.0001) and spleens (0.29 vs. 0.22 kg, P < 0.01), and T2DM men had less cardiac mass than controls (0.25 vs. 0.30 kg, P < 0.001). In this sample, T2DM is characterized by less relative skeletal muscle and cardiac mass in conjunction with larger kidneys, liver, and spleen. Further investigation is needed to establish the causes and metabolic consequences of these race- and sex-specific organ mass differences in T2DM.
与非糖尿病健康对照组相比，2型糖尿病（T2DM）成人的瘦体重（LBM）组成，尤其是骨骼肌和腹部器官是否存在差异，尚未得到研究。来自“展望未来（糖尿病健康行动）”试验的一部分患有T2DM的非裔美国人和白人参与者接受了身体成分评估，并与健康对照样本进行了比较。使用连续切片磁共振成像（MRI）协议对骨骼肌质量（SMM）、肝脏、肾脏和脾脏质量进行量化。通过心脏门控MRI协议或超声心动图对心脏质量进行量化。使用假定密度将MRI体积转换为质量。双能X射线吸收法评估LBM。使用针对身高、体重、性别、年龄、种族以及糖尿病状态与种族或性别的相互作用进行调整的一般线性模型，患有T2DM的人（n = 95）与对照组（n = 76）相比，LBM（49.7对51.6 kg）和SMM（24.1对25.4 kg）更少，肾脏更大（0.40对0.36 kg）（所有P < 0.01）。患有T2DM的白人肝脏（1.90对1.60 kg，P < 0.0001）和脾脏更大（0.29对0.22 kg，P < 0.01），患有T2DM的男性心脏质量比对照组少（0.25对0.30 kg，P < 0.001）。在这个样本中，T2DM的特征是相对骨骼肌和心脏质量较少，同时肾脏、肝脏和脾脏较大。需要进一步研究以确定T2DM中这些种族和性别特异性器官质量差异的原因和代谢后果。
