两株耐碳青霉烯类肺炎克雷伯菌ST258分离株的基因组序列
Genome Sequences of Two Carbapenemase-Resistant Klebsiella pneumoniae ST258 Isolates.
作者信息
Ramirez Maria Soledad, Xie Gang, Johnson Shannon, Davenport Karen, van Duin David, Perez Federico, Bonomo Robert A, Chain Patrick, Tolmasky Marcelo E
机构信息
Los Alamos National Laboratory, Los Alamos, New Mexico, USA.
University of North Carolina, Chapel Hill, North Carolina, USA.
出版信息
Genome Announc. 2014 Jun 19;2(3):e00558-14. doi: 10.1128/genomeA.00558-14.
Abstract
Klebsiella pneumoniae, an ESKAPE group (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species) pathogen, has acquired multiple antibiotic resistance genes and is becoming a serious public health threat. Here, we report the genome sequences of two representative strains of K. pneumoniae from the emerging K. pneumoniae carbapenemase (KPC) outbreak in northeast Ohio belonging to sequence type 258 (ST258) (isolates Kb140 and Kb677, which were isolated from blood and urine, respectively). Both isolates harbor a blaKPC gene, and strain Kb140 carries blaKPC-2, while Kb677 carries blaKPC-3.
摘要
肺炎克雷伯菌是一种ESKAPE组（粪肠球菌、金黄色葡萄球菌、肺炎克雷伯菌、鲍曼不动杆菌、铜绿假单胞菌和肠杆菌属）病原体，已获得多个抗生素耐药基因，正成为严重的公共卫生威胁。在此，我们报告了来自俄亥俄州东北部新兴的肺炎克雷伯菌碳青霉烯酶（KPC）疫情的两株代表性肺炎克雷伯菌菌株的基因组序列，它们属于序列型258（ST258）（分离株Kb140和Kb677，分别从血液和尿液中分离得到）。两株分离株均携带blaKPC基因，菌株Kb140携带blaKPC - 2，而Kb677携带blaKPC - 3。
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