Eichel Andrea, Bilstein Andreas, Werkhäuser Nina, Mösges Ralph
Institute of Medical Statistics, Informatics and Epidemiology, Faculty of Medicine, University of Cologne, Lindenburger Allee 42, 50931 Cologne, Germany.
Bitop AG, Stockumer Straße 28, 58453 Witten, Germany.
J Allergy (Cairo). 2014;2014:292545. doi: 10.1155/2014/292545. Epub 2014 May 11.
Objectives. The meta-analysis aims to investigate the efficacy of ectoine nasal spray and eye drops in the treatment of allergic rhinitis and rhinoconjunctivitis symptoms. Design and Methods. This meta-analysis is based on yet unpublished data of four studies. Both nasal and eye symptoms were documented in patient diary cards. All scales were transformed into a 4-point scale: 0 = no, 1 = mild, 2 = moderate, and 3 = severe symptoms. Each symptom was analysed individually in a meta-analysis of the area under the curve values as well as in a meta-analysis of pre- and posttreatment comparison. Results. After seven days of treatment with ectoine nasal spray both nasal and ocular symptoms decreased significantly. A strong reduction of symptom severity was shown for the parameters rhinorrhoea (31.76% reduction) and nasal obstruction (29.94% reduction). Furthermore, the meta-analyses of individual symptoms to investigate the strength of effect after seven days of medication intake showed significant improvement for nasal obstruction, rhinorrhoea, nasal itching, sneezing, itching of eyes, and redness of eyes. The improvement of the symptom nasal obstruction was associated with a strong effect 0.53 (±0.26). Conclusions. The ectoine nasal spray and eye drops seem to be equally effective as guideline-recommended medication in the treatment of rhinoconjunctivitis symptoms.
目的。本荟萃分析旨在研究依克多因鼻喷雾剂和滴眼液治疗过敏性鼻炎及鼻结膜炎症状的疗效。
设计与方法。本荟萃分析基于四项研究中尚未发表的数据。患者日记卡记录了鼻部和眼部症状。所有量表均转换为4分制：0 = 无，1 = 轻度，2 = 中度，3 = 重度症状。在曲线下面积值的荟萃分析以及治疗前后比较的荟萃分析中，对每个症状进行单独分析。
结果。使用依克多因鼻喷雾剂治疗七天后，鼻部和眼部症状均显著减轻。流涕（减轻31.76%）和鼻塞（减轻29.94%）等参数显示症状严重程度大幅降低。此外，对用药七天后各症状疗效强度进行的荟萃分析表明，鼻塞、流涕、鼻痒、打喷嚏、眼痒和眼红等症状有显著改善。鼻塞症状的改善与强效作用0.53（±0.26）相关。
结论。依克多因鼻喷雾剂和滴眼液在治疗鼻结膜炎症状方面似乎与指南推荐药物同样有效。
