Choi Kyeong Woon, Hong Seong Woo, Chang Yeo Goo, Lee Woo Yong, Lee Byungmo, Paik In Wook, Lee Hyucksang
Department of Surgery, Inje University Seoul Paik Hospital, Seoul, Korea.
Ann Surg Treat Res. 2014 Jun;86(6):309-13. doi: 10.4174/astr.2014.86.6.309. Epub 2014 May 23.
This study was conducted to evaluate the systemic inflammatory response in colorectal cancer patients, and to estimate the usefulness of the Glasgow prognostic score (GPS) as a prognostic factor.
Patients with biopsy-proven colorectal adenocarcinoma who were operated between April 2005 and December 2008 were enrolled in this study. The GPS was estimated based on the measurement of CRP and serum albumin level. The GPS was compared with other clinicopathological factors. Univariate and multivariate analyses were performed to evaluate the factors affecting cancer-specific survival.
GPS was significantly higher in patients with anemia, thrombocytosis, a high neutrophil to lymphocyte ratio, tumor of the colon, and large tumor. Patient age, gender, serum CEA level, tumor gross appearance, TNM stage, and tumor differentiation were not related with the GPS. In univariate analysis, hemoglobin, CEA, gross appearance of tumor, TNM stage, tumor differentiation, and GPS were associated with cancer-specific survival. In multivariate analysis, TNM stage (III or IV : I or II; hazard ratio [HR], 12.322; P = 0.015), tumor differentiation (poorly differentiated : well or moderately differentiated; HR, 3.112; P = 0.021), and GPS (GPS 2 : GPS 0 or 1; HR, 5.168; P = 0.003) were identified as independent prognostic factors in colorectal cancer.
Our study showed that the GPS was an independent variable from tumor stage and a good and convenient prognostic factor in colorectal cancer patients.
本研究旨在评估结直肠癌患者的全身炎症反应，并评估格拉斯哥预后评分（GPS）作为预后因素的有效性。
本研究纳入了2005年4月至2008年12月间接受手术的经活检证实为结直肠腺癌的患者。基于对CRP和血清白蛋白水平的测量来估算GPS。将GPS与其他临床病理因素进行比较。进行单因素和多因素分析以评估影响癌症特异性生存的因素。
贫血、血小板增多、中性粒细胞与淋巴细胞比值高、结肠癌以及肿瘤体积大的患者GPS显著更高。患者年龄、性别、血清CEA水平、肿瘤大体外观、TNM分期和肿瘤分化与GPS无关。在单因素分析中，血红蛋白、CEA、肿瘤大体外观、TNM分期、肿瘤分化和GPS与癌症特异性生存相关。在多因素分析中，TNM分期（III或IV期：I或II期；风险比[HR]，12.322；P = 0.015）、肿瘤分化（低分化：高分化或中分化；HR，3.112；P = 0.021）和GPS（GPS 2分：GPS 0或1分；HR，5.168；P = 0.003）被确定为结直肠癌的独立预后因素。
我们的研究表明，GPS是独立于肿瘤分期的变量，是结直肠癌患者良好且便捷的预后因素。
