Patel Mihir, Staggs Estela, Thomas Colleen S, Lukens Frank, Wallace Michael, Almansa Cristina
Department of Gastroenterology, Mayo Clinic, Jacksonville, FL, USA.
General Clinical Studies Unit, Mayo Clinic, Jacksonville, FL, USA.
Dig Liver Dis. 2014 Sep;46(9):808-12. doi: 10.1016/j.dld.2014.05.020. Epub 2014 Jun 19.
Bowel cleansing is paramount for colonoscopy quality. Unfortunately, an adequate bowel preparation is often limited by side effects and/or patient's intolerance to bowel preparation solutions. Comparisons among different preparations are limited by the lack of validated instruments designed to assess patient's tolerability.
To develop and validate a simple, comprehensive instrument to assess bowel preparation tolerability in patients undergoing colonoscopy.
Development and validation by phases: Phase I (bibliographic search and questionnaire design); Phase II (assessment of content validity and modification of the questionnaire); Phase III (assessment of reproducibility, final validation, and definitive version of the questionnaire).
The initial draft of the questionnaire was generated based on a systematic literature review and feedback from a panel of consultants. Content validity was tested in a focus group of 25 patients undergoing colonoscopy. Patients' suggestions were reviewed by the research team and a second draft of the questionnaire was generated. Final validation and reproducibility were successfully tested (agreement: 86-100%, kappa: 0.77-1.00) in a convenience sample of 100 patients undergoing bowel preparation with different cleansing solutions.
The Mayo Clinic Bowel Prep Tolerability Questionnaire is a simple, comprehensive instrument suitable to evaluate the tolerability of various types of bowel preparations.
肠道准备对于结肠镜检查的质量至关重要。不幸的是，充分的肠道准备常常受到副作用和/或患者对肠道准备溶液不耐受的限制。不同准备方法之间的比较因缺乏用于评估患者耐受性的有效工具而受到限制。
开发并验证一种简单、全面的工具，用于评估接受结肠镜检查患者的肠道准备耐受性。
分阶段进行开发和验证：第一阶段（文献检索和问卷设计）；第二阶段（内容效度评估和问卷修改）；第三阶段（再现性评估、最终验证和问卷最终版本）。
问卷初稿基于系统的文献综述和一组顾问的反馈生成。在一个由25名接受结肠镜检查的患者组成的焦点小组中测试了内容效度。研究团队审查了患者的建议，并生成了问卷的第二稿。在100名使用不同清洁溶液进行肠道准备的患者的便利样本中成功测试了最终验证和再现性（一致性：86 - 100%，kappa值：0.77 - 1.00）。
梅奥诊所肠道准备耐受性问卷是一种简单、全面的工具，适用于评估各种类型肠道准备的耐受性。
