Yayeh Taddesse, Im Eun Ju, Kwon Tae-Hyung, Roh Seong-Soo, Kim Suk, Kim Ji Hye, Hong Seung-Bok, Cho Jae Youl, Park Nyun-Ho, Rhee Man Hee
Laboratory of Veterinary Physiology and Cell Signaling, College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, Republic of Korea.
Department of Research & Development, Gyeongbuk Institute for Marine Bio-Industry, Uljin 767-813, Republic of Korea; Food Science and Biotechnology Major, Andong National University, Andong 760-749, Republic of Korea.
Int Immunopharmacol. 2014 Sep;22(1):51-8. doi: 10.1016/j.intimp.2014.06.009. Epub 2014 Jun 19.
Eisenia bicyclis is edible brown algae recognized as a rich source of bioactive derivatives mainly phlorotannins reported for their anti-oxidant properties. Of all phlorotannins identified so far, dieckol has shown the most potent effect in anti-inflammatory, radical scavenging and neuroprotective functions. However, whether dieckol up-regulates hemeoxygenase 1 (HO-1) and this mediates its anti-inflammatory effect in murine macrophages remains poorly understood. Dieckol (12.5-50 μM) inhibited nitric oxide production and attenuated inducible nitric oxide synthase, phospho (p)-PI-3K, p-Akt, p-IKK-α/β, p-IκB-α and nuclear p-NF-κBp65 protein expressions, and NF-κB transcriptional activity in LPS (0.1 μg/ml) stimulated murine macrophages. On the other hand, dieckol up-regulated HO-1 which partly mediated its anti-inflammatory effect in murine macrophages. Thus, dieckol appeared to be a potential therapeutic agent against inflammation through HO-1 up-regulation.
海带是一种可食用的褐藻，被认为是生物活性衍生物的丰富来源，主要是具有抗氧化特性的间苯三酚单宁。在迄今为止鉴定出的所有间苯三酚单宁中，eckol在抗炎、自由基清除和神经保护功能方面表现出最显著的效果。然而，eckol是否上调血红素加氧酶1（HO-1）以及这是否介导其在小鼠巨噬细胞中的抗炎作用仍知之甚少。eckol（12.5-50μM）抑制一氧化氮的产生，并减弱脂多糖（0.1μg/ml）刺激的小鼠巨噬细胞中诱导型一氧化氮合酶、磷酸化（p）-PI-3K、p-Akt、p-IKK-α/β、p-IκB-α和核p-NF-κBp65蛋白的表达以及NF-κB转录活性。另一方面，eckol上调HO-1，这部分介导了其在小鼠巨噬细胞中的抗炎作用。因此，eckol似乎是一种通过上调HO-1来对抗炎症的潜在治疗剂。
