Departamento de Genética Molecular y Microbiología, Millenium Institute on Immunology and Immunotherapy, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile, Santiago, Chile.
Departamento de Ciencias Biológicas, Millenium Institute on Immunolgy and Immunotherapy, Facultad Ciencias de la Vida, Universidad Andrés Bello, Santiago, Chile.
Front Immunol. 2020 Jul 23;11:1467. doi: 10.3389/fimmu.2020.01467. eCollection 2020.
Heme oxygenase (HO) is the primary antioxidant enzyme involved in heme group degradation. A variety of stimuli triggers the expression of the inducible HO-1 isoform, which is modulated by its substrate and cellular stressors. A major anti-inflammatory role has been assigned to the HO-1 activity. Therefore, in recent years HO-1 induction has been employed as an approach to treating several disorders displaying some immune alterations components, such as exacerbated inflammation or self-reactivity. Many natural compounds have shown to be effective inductors of HO-1 without cytotoxic effects; among them, most are chemicals present in plants used as food, flavoring, and medicine. Here we discuss some naturally derived compounds involved in HO-1 induction, their impact in the immune response modulation, and the beneficial effect in diverse autoimmune disorders. We conclude that the use of some compounds from natural sources able to induce HO-1 is an attractive lifestyle toward promoting human health. This review opens a new outlook on the investigation of naturally derived HO-1 inducers, mainly concerning autoimmunity.
血红素加氧酶（HO）是参与血红素基团降解的主要抗氧化酶。多种刺激物触发诱导型 HO-1 同工酶的表达，其受到其底物和细胞应激源的调节。HO-1 的活性具有重要的抗炎作用。因此，近年来，HO-1 的诱导已被用作治疗多种表现出一些免疫改变成分的疾病的方法，例如炎症加重或自身反应。许多天然化合物已被证明是 HO-1 的有效诱导剂，而没有细胞毒性作用；其中大多数是存在于用作食物、香料和药物的植物中的化学物质。在这里，我们讨论了一些参与 HO-1 诱导的天然衍生化合物，它们对免疫反应调节的影响，以及在多种自身免疫性疾病中的有益作用。我们得出结论，使用一些能够诱导 HO-1 的天然来源的化合物是一种有吸引力的生活方式，可以促进人类健康。本综述为研究天然来源的 HO-1 诱导剂开辟了新的视角，主要涉及自身免疫。
