Calabrese Edward J, Dhawan Gaurav, Kapoor Rachna
Department of Public Health, Environmental Health Sciences, Morrill I, N344, University of Massachusetts, Amherst, MA, 01003, USA,
Arch Toxicol. 2014 Aug;88(8):1503-17. doi: 10.1007/s00204-014-1295-6. Epub 2014 Jun 24.
This article assesses the therapeutic efficacy of ionizing radiation for the treatment of shoulder tendonitis/bursitis in the USA over the period of its use (human 1936-1961; veterinary 1954-1974). Results from ~3,500 human cases were reported in the clinical case studies over 30 articles, and indicated a high treatment efficacy (>90 %) for patients. Radiotherapy was effective with a single treatment. The duration of treatment effectiveness was prolonged, usually lasting until the duration of the follow-up period (i.e., 1-5 years). Therapeutic effectiveness was reduced for conditions characterized as chronic. Similar findings were reported with race horses in the veterinary literature. These historical findings are consistent with clinical studies over the past several decades in Germany, which have used more rigorous study designs and a broader range of clinical evaluation parameters. Radiotherapy treatment was widely used in the mid twentieth century in the USA, but was abandoned following the discovery of anti-inflammatory drugs and the fear of radiation-induced cancer. That X-ray treatment could be an effective means of treating shoulder tendonitis/bursitis, as a treatment option, and is essentially unknown by the current medical community. This paper is the first comprehensive synthesis of the historical use of X-rays to treat shoulder tendonitis/bursitis and its efficacy in the USA.
本文评估了电离辐射在美国使用期间（人类为1936 - 1961年；兽医领域为1954 - 1974年）治疗肩部肌腱炎/滑囊炎的疗效。30多篇临床病例研究报告了约3500例人类病例的结果，表明对患者的治疗效果很高（>90%）。放射治疗单次治疗即有效。治疗效果的持续时间延长，通常持续到随访期（即1 - 5年）。对于慢性病症，治疗效果会降低。兽医文献中对赛马也有类似的发现。这些历史发现与德国过去几十年的临床研究一致，德国的研究采用了更严格的研究设计和更广泛的临床评估参数。放射治疗在20世纪中叶在美国广泛使用，但在发现抗炎药物以及对辐射诱发癌症的担忧之后被放弃。X射线治疗作为一种治疗选择可能是治疗肩部肌腱炎/滑囊炎的有效手段，而目前医学界对此基本并不了解。本文首次全面综述了X射线在美国治疗肩部肌腱炎/滑囊炎的历史应用及其疗效。
