Jones Lauren J, Norton William H J
University of Leicester, Department of Biology, College of Medicine, Biological Sciences and Psychiatry, Adrian Building, University Rd, Leicester LE1 7RH, UK.
Behav Brain Res. 2015 Jan 1;276:171-80. doi: 10.1016/j.bbr.2014.05.055. Epub 2014 Jun 2.
Aggression is an important adaptive behavior that can be used to monopolize resources such as mates or food, acquire and defend territory and establish dominant hierarchies in social groups. It is also a symptom of several psychiatric disorders including attention-deficit/hyperactivity disorder and schizophrenia. The frequent comorbidity of aggression and psychiatric diseases suggests that common genes and neural circuits may link these disorders. Research using animal models has the potential to uncover these genes and neural circuits despite the difficulty of fully modeling human behavioral disorders. In this review we propose that zebrafish may be a suitable model organism for aggression research with the potential to shed light upon the aggressive symptoms of human diseases.
攻击行为是一种重要的适应性行为，可用于独占配偶或食物等资源、获取和保卫领地以及在社会群体中建立优势等级制度。它也是包括注意力缺陷多动障碍和精神分裂症在内的几种精神疾病的症状。攻击行为与精神疾病的频繁共病表明，共同的基因和神经回路可能将这些疾病联系起来。尽管难以完全模拟人类行为障碍，但使用动物模型进行的研究有潜力揭示这些基因和神经回路。在这篇综述中，我们提出斑马鱼可能是一种适合用于攻击行为研究的模式生物，有潜力阐明人类疾病的攻击症状。
