Centre for BioNano Interactions, School of Chemistry and Chemical Biology, Belfield, Dublin 4, Ireland.
Nat Nanotechnol. 2012 Dec;7(12):779-86. doi: 10.1038/nnano.2012.207.
The search for understanding the interactions of nanosized materials with living organisms is leading to the rapid development of key applications, including improved drug delivery by targeting nanoparticles, and resolution of the potential threat of nanotechnological devices to organisms and the environment. Unless they are specifically designed to avoid it, nanoparticles in contact with biological fluids are rapidly covered by a selected group of biomolecules to form a corona that interacts with biological systems. Here we review the basic concept of the nanoparticle corona and its structure and composition, and highlight how the properties of the corona may be linked to its biological impacts. We conclude with a critical assessment of the key problems that need to be resolved in the near future.
对纳米材料与生物体相互作用的研究正在推动关键应用的快速发展，包括通过靶向纳米粒子来改善药物输送，以及解决纳米技术设备对生物体和环境的潜在威胁。除非专门设计来避免，否则与生物流体接触的纳米粒子会迅速被一组选定的生物分子覆盖，形成与生物系统相互作用的冠。在这里，我们回顾了纳米粒子冠的基本概念及其结构和组成，并强调了冠的特性如何与其生物影响相关联。最后，我们对未来需要解决的关键问题进行了批判性评估。
