The National Hospital for Neurology and Neurosurgery, Queen Square and the Reta Lila Weston Institute of Neurological Studies, UCL, London, UK.
J Neurol Neurosurg Psychiatry. 2014 Aug;85(8):878-81. doi: 10.1136/jnnp-2013-305911. Epub 2013 Nov 20.
In this manuscript we summarize the role of chronic stress as a potential trigger factor for Parkinson's disease. Underlying mechanisms and stress-induced changes to the neuronal networks have been highlighted. Examples of stress induced reversible symptoms that resemble parkinsonism in humans and in animal models raise the question whether emotional stress can cause striatal degeneration in susceptible patients. A Pubmed literature review searching for the terms 'Stress', 'Distress and Parkinson's disease', 'Emotional Distress and Parkinson's disease', 'Stress and Parkinson's disease', 'Prodromal Parkinson's disease', 'Non motor symptoms and Parkinson's disease', 'Paradoxical kinesia', 'Psychogenic parkinsonism', 'Functional somatic syndromes', 'Chronic fatigue syndrome', 'Irritable bowel syndrome', 'Fibromyalgia', 'Dopamine and fibromyalgia', 'Dopamine and chronic fatigue syndrome' and 'Dopamine and irritable bowel syndrome' was carried out until April 2013. Articles were also identified through searches of the authors' own files. Only papers published in English were reviewed. The final reference list was generated on the basis of originality and relevance to the broad scope of this viewpoint.
在本文中，我们总结了慢性应激作为帕金森病潜在触发因素的作用。强调了潜在机制和应激诱导的神经网络变化。应激诱导的可逆症状的例子，如人类和动物模型中的帕金森症，提出了一个问题，即情绪应激是否会导致易感患者的纹状体退化。通过 Pubmed 文献检索，搜索了“Stress”、“Distress and Parkinson's disease”、“Emotional Distress and Parkinson's disease”、“Stress and Parkinson's disease”、“Prodromal Parkinson's disease”、“Non motor symptoms and Parkinson's disease”、“Paradoxical kinesia”、“Psychogenic parkinsonism”、“Functional somatic syndromes”、“Chronic fatigue syndrome”、“Irritable bowel syndrome”、“Fibromyalgia”、“Dopamine and fibromyalgia”、“Dopamine and chronic fatigue syndrome”和“Dopamine and irritable bowel syndrome”等术语，检索截至 2013 年 4 月。还通过作者自己的文件搜索来确定文章。仅审查了以英文发表的论文。最终的参考文献列表是基于原创性和与这一观点的广泛范围的相关性生成的。
