Kim Inah, Ha Jaehyeok, Lee June-Hee, Yoo Kye-Mook, Rho Jaehoon
Department of occupational health, Yonsei University Graduate School of Public Health, Seoul, Korea ; Institutes for Occupational Health, Yonsei University College of Medicine, Seoul, Korea.
Department of occupational health, Seoul National University Graduate School of Public Health, Seoul, Korea.
Ann Occup Environ Med. 2014 Jun 3;26:12. doi: 10.1186/2052-4374-26-12. eCollection 2014.
Trichloroethylene (TCE) has been widely used as a degreasing agent in many manufacturing industries. Recently, the International Agency for Research on Cancer presented "sufficient evidence" for the causal relationship between TCE and kidney cancer. The aim of this study was to review the epidemiologic evidences regarding the relationship between TCE exposure and kidney cancer in Korean work environments. The results from the cohort studies were inconsistent, but according to the meta-analysis and case-control studies, an increased risk for kidney cancer was present in the exposure group and the dose-response relationship could be identified using various measures of exposure. In Korea, TCE is a commonly used chemical for cleaning or degreasing processes by various manufacturers; average exposure levels of TCE vary widely. When occupational physicians evaluate work-relatedness kidney cancers, they must consider past exposure levels, which could be very high (>100 ppm in some cases) and associated with jobs, such as plating, cleaning, or degreasing. The exposure levels at a manual job could be higher than an automated job. The peak level of TCE could also be considered an important exposure-related variable due to the possibility of carcinogenesis associated with high TCE doses. This review could be a comprehensive reference for assessing work-related TCE exposure and kidney cancer in Korea.
三氯乙烯（TCE）在许多制造业中被广泛用作脱脂剂。最近，国际癌症研究机构提出了TCE与肾癌之间因果关系的“充分证据”。本研究的目的是回顾韩国工作环境中TCE暴露与肾癌关系的流行病学证据。队列研究的结果并不一致，但根据荟萃分析和病例对照研究，暴露组中肾癌风险增加，并且可以使用各种暴露测量方法确定剂量反应关系。在韩国，TCE是各种制造商在清洁或脱脂过程中常用的化学品；TCE的平均暴露水平差异很大。当职业医生评估与工作相关的肾癌时，他们必须考虑过去的暴露水平，其可能非常高（在某些情况下>100 ppm），并且与电镀、清洁或脱脂等工作相关。体力工作的暴露水平可能高于自动化工作。由于高剂量TCE与致癌作用的可能性，TCE的峰值水平也可被视为一个重要的暴露相关变量。本综述可为评估韩国与工作相关的TCE暴露和肾癌提供全面参考。
