Torres Joao, Gutierres Manuel, Lopes M Ascenção, Santos J Domingos, Cabral A T, Pinto R, van Eck Carola
Faculty of Medicine, University of Porto, Alameda Hernani Monteiro, 4200-319 Porto, Portugal ; Hospital S. Joao, Alameda Professor Hernâni Monteiro, 4200-319 Porto, Portugal.
CEMUC, Faculdade de Engenharia, Universidade do Porto, Rua Doutor Roberto Frias, 4200-465 Porto, Portugal.
Biomed Res Int. 2014;2014:451781. doi: 10.1155/2014/451781. Epub 2014 May 14.
Intertrochanteric hip fractures occur in the proximal femur. They are very common in the elderly and are responsible for high rates of morbidity and mortality. The authors hypothesized that adding an autologous bone marrow stem cells concentrate (ABMC) to a hydroxyapatite scaffold and placing it in the fracture site would improve the outcome after surgical fixation of intertrochanteric hip fractures.
30 patients were randomly selected and divided into 2 groups of 15 patients, to receive either the scaffold enriched with the ABMC (Group A) during the surgical procedure, or fracture fixation alone (Group B).
There was a statistically significant difference in favor of group A at days 30, 60, and 90 for Harris Hip Scores (HHS), at days 30 and 60 for VAS pain scales, for bedridden period and time taken to start partial and total weight bearing (P < 0.05).
These results show a significant benefit of adding a bone marrow enriched scaffold to surgical fixation in intertrochanteric hip fractures, which can significantly reduce the associated morbidity and mortality rates.
Bone marrow stem cells added to a hydroxyapatite scaffold result in better outcomes after surgical treatment of intertrochanteric hip fractures.
股骨转子间骨折发生于股骨近端。此类骨折在老年人中极为常见，且导致高发病率和死亡率。作者推测，将自体骨髓干细胞浓缩液（ABMC）添加到羟基磷灰石支架中并置于骨折部位，会改善股骨转子间骨折手术固定后的疗效。
随机选取30例患者，分为两组，每组15例。一组在手术过程中接受富含ABMC的支架（A组），另一组仅接受骨折固定（B组）。
在术后30天、60天和90天的Harris髋关节评分（HHS）、术后30天和60天的视觉模拟评分（VAS）疼痛量表、卧床时间以及开始部分和完全负重的时间方面，A组均有统计学显著差异（P < 0.05）。
这些结果表明，在股骨转子间骨折手术固定中添加富含骨髓的支架有显著益处，可显著降低相关的发病率和死亡率。
在羟基磷灰石支架中添加骨髓干细胞可使股骨转子间骨折手术治疗后获得更好的疗效。
