Han Jung Mi, Jo An Na, Lee Seung Min, Bae Hyun Suk, Jun Dae Won, Cho Yong Kyun, Suk Ki Tae, Yoon Jai Hoon, Ahn Sang Bong, Cho Yong Jin, Kim Seong Woo, Jang Eun Chul
J Gastroenterol Hepatol. 2014 Jun;29(6):1265-72. doi: 10.1111/jgh.12520.
Dietary factors are closely associated with the risk of non-alcoholic fatty liver disease (NAFLD). Asian and Western diets differ in energy-nutrient composition, fatty-acid composition, and main nutritional sources; therefore, the implications would be limited if the Western-oriented study results were applied to Asian patients. We aimed to identify the nutrient and food group intakes of a typical Asian diet and assess their effects on NAFLD risk.
In total, 348 subjects were recruited from 5 participating hospitals. Information on sociodemographic characteristics and health-related behaviors were obtained through face-to-face interviews. NAFLD was diagnosed by ultrasound. Dietary intakes were assessed with a 24-h recall applying a multiple-pass approach and 4-day food records that included 1 or 2 weekend days.
There were no significant differences in health-related behaviors between the cases and controls except for smoking behavior. The cases had elevated triacylglycerol, fasting glucose, and low-density lipoprotein cholesterol levels compared with the controls. In men, after adjusting for variables, low intakes of vitamin C (odds ratio [OR], 4.23), vitamin K (OR, 3.93), folate (OR, 3.37), omega-3 fatty acids (OR, 2.16), and nuts and seeds (OR, 3.66) were associated with a significantly higher risk for developing NAFLD. In women, vitamin K (OR, 2.54) and vegetable (OR, 4.11) intakes showed a significant beneficial effect for lowering NAFLD risk.
Adequate intakes of vitamin C, vitamin K, folate, omega-3 fatty acids, nuts and seeds, and vegetables may help in preventing NAFLD in Korean adults.
饮食因素与非酒精性脂肪性肝病（NAFLD）风险密切相关。亚洲饮食与西方饮食在能量营养素组成、脂肪酸组成及主要营养来源方面存在差异；因此，若将以西方为导向的研究结果应用于亚洲患者，其意义将十分有限。我们旨在确定典型亚洲饮食的营养素和食物组摄入量，并评估它们对NAFLD风险的影响。
总共从5家参与研究的医院招募了348名受试者。通过面对面访谈获取社会人口学特征和健康相关行为的信息。通过超声诊断NAFLD。采用多遍法的24小时回顾法和包括1或2个周末日的4天食物记录来评估饮食摄入量。
除吸烟行为外，病例组和对照组在健康相关行为方面无显著差异。与对照组相比，病例组的三酰甘油、空腹血糖和低密度脂蛋白胆固醇水平升高。在男性中，调整变量后，维生素C摄入量低（比值比[OR]，4.23）、维生素K摄入量低（OR，3.93）、叶酸摄入量低（OR，3.37）、ω-3脂肪酸摄入量低（OR，2.16）以及坚果和种子摄入量低（OR，3.66）与发生NAFLD的风险显著较高相关。在女性中，维生素K摄入量（OR，2.54）和蔬菜摄入量（OR，4.11）对降低NAFLD风险显示出显著的有益作用。
充足摄入维生素C、维生素K、叶酸、ω-3脂肪酸、坚果和种子以及蔬菜可能有助于预防韩国成年人患NAFLD。
