Nussbeck Sara Y, Skrowny Daniela, O'Donoghue Sheila, Schulze Thomas G, Helbing Krister
1 Department of Medical Informatics, University Medical Center Göttingen , Göttingen, Germany .
Biopreserv Biobank. 2014 Jun;12(3):199-205. doi: 10.1089/bio.2013.0085.
Effective tracking of biospecimens within a biobank requires that each biospecimen has a unique identifier (ID). This ID can be found on the sample container as well as in the biospecimen management system. In the latter, the biospecimen ID is the key to annotation data such as location, quality, and sample processing. Guidelines such as the Best Practices from the International Society of Biological and Environmental Repositories only state that a unique identifier should be issued for each sample. However, to our knowledge, all guidelines lack a specific description of how to actually generate such an ID and how this can be supported by an IT system. Here, we provide a guide for biobankers on how to generate a biospecimen ID for your biobank. We also provide an example of how to apply this guide using a longitudinal multi-center research project (and its biobank). Starting with a description of the biobank's purpose and workflows through to collecting requirements from stakeholders and relevant documents (i.e., guidelines or data protection concepts), and existing IT-systems, we describe in detail how a concept to develop an ID system can be developed from this information. The concept contains two parts: one is the generation of the biospecimen ID according to the requirements of stakeholders, existing documentation such as guidelines or data protection concepts, and existing IT-infrastructures, and the second is the implementation of the biospecimen IDs and related functionalities covering the handling of individual biospecimens within an existing biospecimen management system. From describing the concept, the article moves on to how the new concept supports both existing or planned biobank workflows. Finally, the implementation and validation step is outlined to the reader and practical hints are provided for each step.
在生物样本库中有效追踪生物样本要求每个生物样本都有一个唯一标识符（ID）。这个ID可以在样本容器上以及生物样本管理系统中找到。在后者中，生物样本ID是诸如位置、质量和样本处理等注释数据的关键。国际生物和环境样本库协会的最佳实践等指南仅指出应为每个样本发放唯一标识符。然而，据我们所知，所有指南都缺乏关于如何实际生成这样一个ID以及如何由IT系统提供支持的具体描述。在此，我们为生物样本库管理者提供一份关于如何为您的生物样本库生成生物样本ID的指南。我们还提供了一个如何使用纵向多中心研究项目（及其生物样本库）应用本指南的示例。从描述生物样本库的目的和工作流程开始，到收集利益相关者的需求和相关文件（即指南或数据保护概念）以及现有IT系统，我们详细描述了如何根据这些信息开发一个ID系统的概念。这个概念包含两个部分：一是根据利益相关者的要求、现有文件（如指南或数据保护概念）和现有IT基础设施生成生物样本ID，二是在现有的生物样本管理系统中实现生物样本ID及相关功能，涵盖单个生物样本的处理。从描述概念开始，文章接着讲述新的概念如何支持现有或计划中的生物样本库工作流程。最后，向读者概述实施和验证步骤，并为每个步骤提供实用提示。
