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粘连的病理生理学

Pathophysiology of adhesions.

作者信息

Buţureanu S A, Buţureanu T A S

出版信息

Chirurgia (Bucur). 2014 May-Jun;109(3):293-8.

Abstract

Formation of intraperitoneal adhesions after abdominal or pelvic surgery is a very common phenomenon. Although there is no universally accepted definition, they are bridges of scar tissue between the various organs of the peritoneal cavity as a result of a local repair process excessively. Adhesions can be congenital or acquired as a local inflammatory process. Some adhesions can be asymptomatic, but many of them can cause severe complications such as abdominal or pelvic pain, female infertility, and intestinal obstruction. Physicians and patients should be informed of the possibility of postoperative intraperitoneal adhesions and this possibility should be mentioned in the informed consent signed by the patient. The formation of adhesions has multiple proinflammatory mechanisms involved, many with a pathophysiology still incomplete understood. Laparoscopic procedures do not diminish much the possibility of developing postoperative adhesions.Diagnostic imaging is quite uncertain, and the possibilities of preventing with a poor final result. The use of correct surgical technique and avoidance of traumatic intraperitoneal organs maneuvers may help reduce postoperative adhesions incidence.

摘要

腹部或盆腔手术后腹腔内粘连的形成是一种非常常见的现象。尽管目前尚无普遍接受的定义,但它们是腹腔内各器官之间由于局部修复过程过度而形成的瘢痕组织桥。粘连可以是先天性的,也可作为局部炎症过程后天获得。一些粘连可能无症状,但其中许多会导致严重并发症,如腹痛、盆腔疼痛、女性不孕和肠梗阻。应告知医生和患者术后发生腹腔内粘连的可能性,并且这种可能性应在患者签署的知情同意书中提及。粘连的形成涉及多种促炎机制,其中许多的病理生理学仍未完全了解。腹腔镜手术并不能大幅降低术后发生粘连的可能性。诊断性成像相当不确定,预防效果也不佳。采用正确的手术技术并避免对腹腔内器官进行创伤性操作可能有助于降低术后粘连的发生率。

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