幽门螺杆菌胃炎：阿莫西林治疗的长期结果
Campylobacter pylori gastritis: long term results of treatment with amoxycillin.
作者信息
Oderda G, Dell'Olio D, Morra I, Ansaldi N
机构信息
Gastroenterology Service, Department of Paediatrics, University of Turin, Italy.
出版信息
Arch Dis Child. 1989 Mar;64(3):326-9. doi: 10.1136/adc.64.3.326.
Abstract
To evaluate the efficacy of amoxycillin in eradicating Campylobacter pylori, endoscopic biopsy specimens were taken from the antral mucosa of 40 children with gastritis before, immediately after, and (in 30 patients) three months after treatment. Immediately after treatment 34 patients (85%) no longer had the organism in the mucosa, and the gastritis had healed in 23 (58%). Three months later the infection had recurred in 22 of 30 patients (73%), and the gastritis had relapsed in all of them. Significantly more children in whom C pylori recurred had family histories of peptic ulcer disease. The results suggest that amoxycillin alone is ineffective in the long term treatment of C pylori gastritis.
摘要
为评估阿莫西林根除幽门螺杆菌的疗效，对40例胃炎患儿的胃窦黏膜进行内镜活检取材，分别于治疗前、治疗后即刻以及（30例患者）治疗后3个月取材。治疗后即刻，34例患者（85%）胃黏膜中已无该菌，23例（58%）胃炎已愈合。3个月后，30例患者中有22例（73%）感染复发，且所有复发患者的胃炎均复发。幽门螺杆菌复发的患儿中，有消化性溃疡病家族史的显著更多。结果表明，单独使用阿莫西林对幽门螺杆菌性胃炎的长期治疗无效。
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