Incebiyik Adnan, Seker Ahmet, Vural Mehmet, Gul Hilali Nese, Camuzcuoglu Aysun, Camuzcuoglu Hakan
Faculty of Medicine, Department of Gynecology and Obstetrics, Harran University, Yenisehir Campus, 63300, Sanlıurfa, Turkey,
Wien Klin Wochenschr. 2014 Jul;126(13-14):422-6. doi: 10.1007/s00508-014-0560-2. Epub 2014 Jun 24.
Our aim in this study was to investigate whether mean platelet volume (MPV) value could be used as an early marker to predict pelvic inflammatory disease (PID).
Overall, 44 patients with PID and 44 healthy women were included in the study. The control group consisted of 44 women who applied to the clinic for a routine gynaecological check-up, without chronic disease or a history of medication use. Owing to the fact that it would affect thrombocyte function, women who have the following conditions were excluded from the study: women who were taking anticoagulant therapy, oral contraceptives, nonsteroid anti-inflammatory medications and who had chronic diseases. The leukocyte count, platelet count, neutrophil ratio and MPV values were collected from PID and the control group. C reactive protein values of patients with PID were also noted.
MPV values in patients with PID were lower than those in the control group. This reduction in MPV is statistically significant when the PID patient group is compared with the control group (p < 0.001). A negative correlation was discovered between platelet count and MPV values (p = 0.019, r = - 0.425). Receiver-operating curve analysis pointed out that MPV has greater area under curve value than neutrophil rate, leukocyte and platelet count (0.73, 0.64, 0.72 and 0.49 respectively).
Since the MPV value was significantly decreased in patients with PID, it may serve as an additional and even more valuable marker than leukocyte count in the diagnosis of PID.
本研究的目的是调查平均血小板体积（MPV）值是否可作为预测盆腔炎（PID）的早期标志物。
本研究共纳入44例PID患者和44例健康女性。对照组由44名到诊所进行常规妇科检查、无慢性病或用药史的女性组成。由于以下情况会影响血小板功能，患有以下疾病的女性被排除在研究之外：正在接受抗凝治疗、口服避孕药、非甾体抗炎药治疗以及患有慢性病的女性。收集PID组和对照组的白细胞计数、血小板计数、中性粒细胞比例和MPV值。还记录了PID患者的C反应蛋白值。
PID患者的MPV值低于对照组。当将PID患者组与对照组进行比较时，MPV的这种降低具有统计学意义（p < 0.001）。发现血小板计数与MPV值之间存在负相关（p = 0.019，r = -0.425）。受试者工作曲线分析指出，MPV的曲线下面积值大于中性粒细胞率、白细胞和血小板计数（分别为0.73、0.64、0.72和0.49）。
由于PID患者的MPV值显著降低，它可能作为PID诊断中比白细胞计数更有价值的附加标志物。
