Department of Clinical Laboratory, The First Affiliated Hospital of Guangxi Medical University, Guangxi Zhuang Autonomous Region, Nanning, China.
J Ovarian Res. 2018 Jan 22;11(1):10. doi: 10.1186/s13048-018-0382-3.
Cancer is widely believed to result from chronic inflammation, and red cell distribution width (RDW) and mean platelet volume (MPV) are considered as inflammatory markers for cancer. We investigated the values of RDW, MPV, and cancer antigen 125 (CA125), alone or in combination, for distinguishing between ovarian cancer and benign ovarian tumors.
The study included 326 patients with ovarian cancer, 290 patients with benign ovarian tumors, and 162 control subjects. Hematologic tests were performed at initial diagnosis.
RDW was increased and MPV was decreased in the ovarian cancer group compared with the control and benign ovarian tumor groups. RDW was positively correlated and MPV was negatively correlated with cancer stage. Area under the curve (AUC) analysis for ovarian cancer versus benign ovarian tumors revealed that the specificity and sensitivity were increased for the combination of MPV and CA125 compared with either marker alone, and the specificity was increased for the combination of RDW and CA125, compared with either alone. The AUCs for RDW plus CA125 and MPV plus CA125 were significantly larger than for any of the markers alone.
In conclusion, combinations of the markers RDW, MPV, and CA125 may improve the differential diagnosis of ovarian cancer and benign ovarian tumors.
人们普遍认为癌症是由慢性炎症引起的，红细胞分布宽度（RDW）和平均血小板体积（MPV）被认为是癌症的炎症标志物。我们研究了 RDW、MPV 和癌抗原 125（CA125）单独或联合用于区分卵巢癌和良性卵巢肿瘤的价值。
该研究纳入了 326 例卵巢癌患者、290 例良性卵巢肿瘤患者和 162 例对照。在初始诊断时进行了血液学检查。
与对照组和良性卵巢肿瘤组相比，卵巢癌组的 RDW 升高，MPV 降低。RDW 与癌症分期呈正相关，MPV 与癌症分期呈负相关。卵巢癌与良性卵巢肿瘤的曲线下面积（AUC）分析显示，MPV 和 CA125 的组合与任一标志物单独相比，特异性和敏感性均增加，RDW 和 CA125 的组合与任一标志物单独相比，特异性增加。RDW 加 CA125 和 MPV 加 CA125 的 AUC 明显大于任何单一标志物。
综上所述，RDW、MPV 和 CA125 标志物的组合可能改善卵巢癌和良性卵巢肿瘤的鉴别诊断。
