不同激光照射对环磷酰胺诱导大鼠白细胞减少症的影响。
The effect of different laser irradiation on cyclophosphamide-induced leucopenia in rats.
机构信息
Acupuncture & Tuina College, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
出版信息
Evid Based Complement Alternat Med. 2014;2014:756406. doi: 10.1155/2014/756406. Epub 2014 May 14.
Objective. To assess the effect of different lasers on cyclophosphamide- (CTX-) induced leucopenia in rats. Methods. 11 rats were normal control and 55 rats were injected with a dose of 80 mg/kg CTX for the first time and 40 mg/kg on the 6th and the 11th days to establish a leucopenia model. Rats of the irradiation groups received a 5-minute laser irradiation with either single 10.6 μ m or 650 nm laser or alternatively 10.6 μ m-650 nm laser irradiation, besides a sham treatment on acupoint Dazhui (DU 14) and acupoint Zusanli (ST 36) of both sides, 8 times for 16 days. Normal and model control group received no treatment. Results. On day 16 after the first CTX injection, the WBC counts from all the laser irradiation groups were significantly higher than those from the model control and the sham group (P < 0.05), while there were no significant differences compared with the normal control (P > 0.05). The TI of 10.6 μ m-650 nm laser irradiation group was significantly higher than that of the model control group (P < 0.05). Conclusions. The single and combined 10.6 μ m and 650 nm laser irradiation on ST36 and DU14 accelerated the recovery of the WBC count in the rats with leucopenia.
目的。评估不同激光对环磷酰胺（CTX）诱导的大鼠白细胞减少症的影响。
方法。将 11 只大鼠作为正常对照组，55 只大鼠首次注射 80mg/kg CTX，第 6 天和第 11 天注射 40mg/kg，建立白细胞减少症模型。照射组大鼠接受 5 分钟的激光照射，分别为单次 10.6μm 或 650nm 激光，或交替进行 10.6μm-650nm 激光照射，双侧穴位大椎（DU 14）和足三里（ST 36）假处理，共 16 天 8 次。正常对照组和模型对照组均未进行治疗。
结果。首次 CTX 注射后 16 天，所有激光照射组的白细胞计数均明显高于模型对照组和假处理组（P<0.05），但与正常对照组相比无显著差异（P>0.05）。10.6μm-650nm 激光照射组的 TI 明显高于模型对照组（P<0.05）。
结论。ST36 和 DU14 处的单次和联合 10.6μm 和 650nm 激光照射加速了白细胞减少症大鼠白细胞计数的恢复。
Zotero 插件