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激光针刺通过调节海马体中、、、和基因表达发挥神经保护作用。

Laser Acupuncture Exerts Neuroprotective Effects via Regulation of , , , and Gene Expressions in the Hippocampus.

作者信息

Yun Yeong-Chan, Jang Dongyeop, Yoon Sun-Bee, Kim Dohyeong, Choi Dong-Hee, Kwon O-Sang, Lee Yu-Mi, Youn Daehwan

机构信息

Department of Meridian and Acupuncture Point, College of Korean Medicine, Dongshin University, 185, Geonjae-ro, Naju, Republic of Korea.

Acupuncture, Moxibustion, and Acupuncture Point Research Group, Korea Institute of Oriental Medicine, 1672, Yuseong-daero, Yuseong-gu, Daejeon, Republic of Korea.

出版信息

Evid Based Complement Alternat Med. 2017;2017:7181637. doi: 10.1155/2017/7181637. Epub 2017 Mar 20.

DOI:10.1155/2017/7181637
PMID:28408940
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5376935/
Abstract

Acupuncture has a positive effect on cognitive deficits. However, the effects of laser acupuncture (LA) on cognitive function and its mechanisms of action are unclear. The present study aimed to evaluate the effects of LA on middle cerebral artery occlusion- (MCAO-) induced cognitive impairment and its mechanisms of action. Transient focal cerebral ischemia was modeled in adult Sprague-Dawley rats by MCAO. After LA or manual-acupuncture (MA) treatment at the GV20 and HT7 for 2 weeks, hippocampal-dependent memory was evaluated using the Morris water maze (MWM) test. The hippocampus was dissected to analyze choline acetyltransferase (ChAT) immunoreactivity and , , , and gene expressions. MWM test demonstrated a significant improvement in hippocampal-dependent memory in the MCAO rats after LA treatment. LA treatment significantly reversed the postischemic decrease in ChAT immunoreactivity in the hippocampal CA1 region. LA treatment significantly normalized gene expression in the hippocampus which had been altered by MCAO, especially upregulating gene expression of Creb, Bdnf, and Bcl-2 and downregulating gene expression of Bax. This study suggests that LA treatment could improve cognitive impairment in MCAO rats to enhance the cholinergic system in the hippocampal CA1 region and to exert a neuroprotective effect by regulating , , , and gene expressions.

摘要

针刺对认知缺陷有积极作用。然而，激光针刺（LA）对认知功能的影响及其作用机制尚不清楚。本研究旨在评估LA对大脑中动脉闭塞（MCAO）诱导的认知障碍的影响及其作用机制。通过MCAO在成年Sprague-Dawley大鼠中建立短暂性局灶性脑缺血模型。在GV20和HT7处进行LA或手动针刺（MA）治疗2周后，使用莫里斯水迷宫（MWM）试验评估海马依赖性记忆。解剖海马以分析胆碱乙酰转移酶（ChAT）免疫反应性以及、、和基因表达。MWM试验表明，LA治疗后MCAO大鼠的海马依赖性记忆有显著改善。LA治疗显著逆转了海马CA1区缺血后ChAT免疫反应性的降低。LA治疗使MCAO改变的海马基因表达显著恢复正常，特别是上调Creb、Bdnf和Bcl-2的基因表达并下调Bax的基因表达。本研究表明，LA治疗可改善MCAO大鼠的认知障碍，增强海马CA1区的胆碱能系统，并通过调节、、和基因表达发挥神经保护作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6ea/5376935/1bd96956a011/ECAM2017-7181637.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6ea/5376935/5b559da43db7/ECAM2017-7181637.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6ea/5376935/adc3787ffec6/ECAM2017-7181637.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6ea/5376935/8ce86d117ebb/ECAM2017-7181637.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6ea/5376935/0962543316ec/ECAM2017-7181637.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6ea/5376935/e70370fb4302/ECAM2017-7181637.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6ea/5376935/1bd96956a011/ECAM2017-7181637.006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6ea/5376935/5b559da43db7/ECAM2017-7181637.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6ea/5376935/adc3787ffec6/ECAM2017-7181637.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6ea/5376935/8ce86d117ebb/ECAM2017-7181637.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6ea/5376935/0962543316ec/ECAM2017-7181637.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6ea/5376935/e70370fb4302/ECAM2017-7181637.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b6ea/5376935/1bd96956a011/ECAM2017-7181637.006.jpg

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2
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J Acupunct Meridian Stud. 2015 Aug;8(4):183-91. doi: 10.1016/j.jams.2015.06.008. Epub 2015 Jun 19.
3
Electro-acupuncture improves the social interaction behavior of rats.
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J Physiol Sci. 2024 Oct 3;74(1):49. doi: 10.1186/s12576-024-00941-4.
4
Photobiomodulation Therapy on Brain: Pioneering an Innovative Approach to Revolutionize Cognitive Dynamics.光生物调节疗法对大脑的影响：开创革新方法，改变认知动态。
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5
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6
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5
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