Qi Yuangang, Zhang Qing, Huang Yong, Wang Daoqing
Department of Radiology, Affiliated Hospital of Shandong Academy of Medical Sciences, Jinan, Shandong 250032, P.R. China.
Department of Radiology, Shandong Cancer Hospital, Jinan, Shandong 250114, P.R. China.
Oncol Lett. 2014 Jul;8(1):285-290. doi: 10.3892/ol.2014.2065. Epub 2014 Apr 15.
The aim of the present study was to analyze and improve the understanding of computed tomography (CT) and positron emission tomography (PET)/CT imaging and the pathological features of solitary thin-walled cavity lung cancer. A total of 16 patients with pathologically confirmed solitary thin-walled cavity lung cancer were included in the present study. All of the patients received CT scans. Among these, two patients underwent an additional PET/CT examination. The CT and PET/CT images were analyzed and a cross-check analysis of the pathological results was conducted. In total, 16 cases of lesions demonstrated thin-walled cavities on the CT images. Among these cases, three presented with an uneven thickening of the cavity walls, 10 cases exhibited wall nodules and three cases presented with compartments in the cavity. The standard uptake value (SUV) of the cavity wall increased in two patients who underwent PET/CT examinations. The 16 cases of lesions were pathologically confirmed as adenocarcinomas. Light microscopy revealed that the tumor cells, which were observed in 12 cases of lesions, had diffused along the inner cavity wall and the tumor cells of four cases had invaded the bronchial wall. Images of the chest that demonstrated a single thin-walled cavity accompanied by uneven thickening of the cavity wall or wall nodules, in addition to an increase in the SUV and compartments in the cavity, indicated potential lung cancer. Valves formed as a result of bronchial wall damage may have led to the cavity.
本研究的目的是分析并增进对计算机断层扫描（CT）和正电子发射断层扫描（PET）/CT成像以及孤立性薄壁空洞型肺癌病理特征的理解。本研究共纳入16例经病理证实的孤立性薄壁空洞型肺癌患者。所有患者均接受了CT扫描。其中，2例患者还接受了PET/CT检查。对CT和PET/CT图像进行了分析，并对病理结果进行了交叉核对分析。总共16例病变在CT图像上显示为薄壁空洞。在这些病例中，3例表现为空洞壁增厚不均匀，10例有壁结节，3例有空洞内分隔。接受PET/CT检查的2例患者空洞壁的标准化摄取值（SUV）升高。16例病变经病理证实为腺癌。光学显微镜检查显示，12例病变中观察到的肿瘤细胞沿内腔壁扩散，4例病变的肿瘤细胞侵犯了支气管壁。胸部图像显示单个薄壁空洞，伴有空洞壁增厚不均匀或壁结节，此外SUV升高和有空洞内分隔，提示可能为肺癌。支气管壁损伤形成的活瓣可能导致了空洞的形成。
