Singh Santokh, Chand Gian, Charan Shiv, Arora Sahil, Singh Parampreet
Professor and Head, Department of Medicine, Government Medical College , Amritsar, Punjab, India .
Associate Professor, Department of Medicine, Government Medical College , Amritsar, Punjab, India .
J Clin Diagn Res. 2014 Apr;8(4):MD01-2. doi: 10.7860/JCDR/2014/7840.4250. Epub 2014 Apr 15.
Secondary pure red cell aplasia is usually seen in immunocompromised hosts or patients who have chronic haemolytic anaemia, which is caused by blood transfusion related transmission. The present patient, a 30-year-old immunocompetent female, presented several times with recurrent severe anaemia, over a period of one and half years. Her history, clinical examination and investigations did not reveal any indigenous drug intake, previous blood transfusions, haemolytic disorders, myeloproliferative disorders, pregnancies, autoimmune diseases or thymoma. She was found to have a thalassaemia minor trait, on the basis of which severity and recurrence of anaemia could not be explained, and on further evaluation, she was diagnosed to have acute aplastic crisis caused by Parvovirus B19 induced, acquired pure red cell aplasia. The co- existence of these two haematological disorders in an immunocompetent, non-transfusion dependent individual is rare, which makes our case report unique.
继发性纯红细胞再生障碍通常见于免疫功能低下的宿主或患有慢性溶血性贫血的患者，后者由输血相关传播引起。本例患者为一名30岁免疫功能正常的女性，在一年半的时间里多次出现反复严重贫血。她的病史、临床检查和各项检查均未发现服用任何本土药物、既往输血史、溶血性疾病、骨髓增殖性疾病、妊娠史、自身免疫性疾病或胸腺瘤。基于她存在轻度地中海贫血特征，无法解释贫血的严重程度和复发情况，经进一步评估，她被诊断为由细小病毒B19诱导的获得性纯红细胞再生障碍导致的急性再生障碍危象。这两种血液系统疾病在免疫功能正常、非输血依赖个体中的并存情况罕见，这使得我们的病例报告具有独特性。
