Bhatti Sabha, Al-Khalidi Hussein, Hor Kan, Hakeem Abdul, Taylor Michael, Quyyumi Arshed A, Oshinski John, Pecora Andrew L, Kereiakes Dean, Chung Eugene, Pedrizzetti Gianni, Miszalski-Jamka Tomasz, Mazur Wojciech
University of Cincinnati Hospital, Cincinnati, OH, USA.
Duke University School of Medicine, Durham, NC, USA.
ISRN Radiol. 2012 Sep 29;2013:371028. doi: 10.5402/2013/371028. eCollection 2013.
Background. Magnetic resonance imaging (MRI) strain analysis is a sensitive method to assess myocardial function. Our objective was to define the feasibility of MRI circumferential strain (ε cc) analysis in assessing subtle changes in myocardial function following stem cell therapy. Methods and Results. Patients in the Amorcyte Phase I trial were randomly assigned to treatment with either autologous bone-marrow-derived stem cells infused into the infarct-related artery 5 to 11 days following primary PCI or control. MRI studies were obtained at baseline, 3, and 6 months. ε cc was measured in the short axis views at the base, mid and apical slices of the left ventricle (LV) for each patient (13 treatments and 10 controls). Mid-anterior LV ε cc improved between baseline -18.5 ± 8.6 and 3 months -22.6 ± 7.0, P = 0.03. There were no significant changes in ε cc at 3 months and 6 months compared to baseline for other segments. There was excellent intraobserver and interobserver agreement for basal and mid circumferential strain. Conclusion. MRI segmental strain analysis is feasible in assessment of regional myocardial function following cell therapy with excellent intra- and inter-observer variability's. Using this method, a modest interval change in segmental ε cc was detected in treatment group.
背景。磁共振成像（MRI）应变分析是评估心肌功能的一种敏感方法。我们的目的是确定MRI圆周应变（εcc）分析在评估干细胞治疗后心肌功能细微变化方面的可行性。方法与结果。Amorcyte I期试验中的患者被随机分配接受以下治疗：在初次PCI术后5至11天，将自体骨髓来源的干细胞注入梗死相关动脉，或作为对照。在基线、3个月和6个月时进行MRI研究。对每位患者（13例治疗组和10例对照组）在左心室（LV）底部、中部和心尖切片的短轴视图中测量εcc。左心室中部前壁的εcc从基线时的-18.5±8.6改善至3个月时的-22.6±7.0，P = 0.03。与基线相比，其他节段在3个月和6个月时的εcc无显著变化。基底和中部圆周应变的观察者内和观察者间一致性良好。结论。MRI节段应变分析在评估细胞治疗后的局部心肌功能方面是可行的，观察者内和观察者间的变异性良好。使用这种方法，在治疗组中检测到节段εcc有适度的间隔变化。
