Nilius Bernd, Flockerzi Veit
Department Cell Mol Medicine, Laboratory Ion Channel Research, KU Leuven, Campus Gasthuisberg, O&N 1, Herestraat 49-Bus 802, 3000, Leuven, Belgium,
Handb Exp Pharmacol. 2014;223:1239-80. doi: 10.1007/978-3-319-05161-1_20.
TRP channels comprise one of the most rapid growing research topics in ion channel research, in fields related to ion channels including channelopathies and translational medicine. We provide here a critical survey on our current knowledge of TRP channels and highlight some of the still open or controversial questions. This comprises questions related to evolution of TRP channels; biophysics, i.e., permeation; pore properties and gating; modulation; the still-elusive 3D structure; and channel subunits but also their role as general sensory channels and in human diseases. We will conclude that our knowledge on TRP channels is still at the very beginning of an exciting research journey.
在离子通道研究领域，包括通道病和转化医学等与离子通道相关的领域中，瞬时受体电位（TRP）通道是研究进展最为迅速的课题之一。在此，我们对目前关于TRP通道的知识进行批判性综述，并突出一些仍未解决或存在争议的问题。这包括与TRP通道进化相关的问题；生物物理学，即通透；孔道特性与门控；调节；仍然难以捉摸的三维结构；通道亚基，以及它们作为一般感觉通道的作用和在人类疾病中的作用。我们将得出结论，我们对TRP通道的了解仍处于激动人心的研究旅程的起步阶段。
