Brachet E, Ghosh T, Ghosh I, König B
University of Regensburg Faculty of Chemistry and Pharmacy , Institute of Organic Chemistry , Universitätsstraße 31 , 93053 Regensburg , Germany . Email:
Chem Sci. 2015 Feb 1;6(2):987-992. doi: 10.1039/c4sc02365j. Epub 2014 Oct 30.
Benzoyl azides were used for the direct and atom economic C-H amidation of electron rich heteroarenes in the presence of phosphoric acid, a photocatalyst and visible light. Hetero-aromatic amides are obtained in good yields at very mild reaction conditions with dinitrogen as the only by-product. The reaction allows the use of aryl-, heteroaryl- or alkenyl acyl azides and has a wide scope for heteroarenes, including pyrroles, indole, furan, benzofuran and thiophene giving good regio-selectivities and yields.
在磷酸、光催化剂和可见光存在的条件下，苯甲酰叠氮用于富电子杂芳烃的直接且原子经济的C-H酰胺化反应。在非常温和的反应条件下，以氮气作为唯一副产物，可高产率地得到杂芳族酰胺。该反应允许使用芳基、杂芳基或烯基酰基叠氮，并且对杂芳烃具有广泛的适用性，包括吡咯、吲哚、呋喃、苯并呋喃和噻吩，可给出良好的区域选择性和产率。
